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Items: 1 to 20 of 159

1.

A persulfidation-based mechanism controls aquaporin-8 conductance.

Bestetti S, Medraño-Fernandez I, Galli M, Ghitti M, Bienert GP, Musco G, Orsi A, Rubartelli A, Sitia R.

Sci Adv. 2018 May 2;4(5):eaar5770. doi: 10.1126/sciadv.aar5770. eCollection 2018 May.

2.

Role of Selenof as a Gatekeeper of Secreted Disulfide-Rich Glycoproteins.

Yim SH, Everley RA, Schildberg FA, Lee SG, Orsi A, Barbati ZR, Karatepe K, Fomenko DE, Tsuji PA, Luo HR, Gygi SP, Sitia R, Sharpe AH, Hatfield DL, Gladyshev VN.

Cell Rep. 2018 May 1;23(5):1387-1398. doi: 10.1016/j.celrep.2018.04.009.

3.

The unconventional secretion of IL-1β: Handling a dangerous weapon to optimize inflammatory responses.

Sitia R, Rubartelli A.

Semin Cell Dev Biol. 2018 Nov;83:12-21. doi: 10.1016/j.semcdb.2018.03.011. Epub 2018 Apr 5. Review.

PMID:
29571971
4.

Redox crosstalk at endoplasmic reticulum (ER) membrane contact sites (MCS) uses toxic waste to deliver messages.

Yoboue ED, Sitia R, Simmen T.

Cell Death Dis. 2018 Feb 28;9(3):331. doi: 10.1038/s41419-017-0033-4. Review.

5.

Ratiometric sensing of BiP-client versus BiP levels by the unfolded protein response determines its signaling amplitude.

Bakunts A, Orsi A, Vitale M, Cattaneo A, Lari F, Tadè L, Sitia R, Raimondi A, Bachi A, van Anken E.

Elife. 2017 Dec 18;6. pii: e27518. doi: 10.7554/eLife.27518.

6.

A peptide extension dictates IgM assembly.

Pasalic D, Weber B, Giannone C, Anelli T, Müller R, Fagioli C, Felkl M, John C, Mossuto MF, Becker CFW, Sitia R, Buchner J.

Proc Natl Acad Sci U S A. 2017 Oct 10;114(41):E8575-E8584. doi: 10.1073/pnas.1701797114. Epub 2017 Sep 27.

7.

Cysteines as Redox Molecular Switches and Targets of Disease.

Fra A, Yoboue ED, Sitia R.

Front Mol Neurosci. 2017 Jun 6;10:167. doi: 10.3389/fnmol.2017.00167. eCollection 2017. Review.

8.

Dysregulated IL-1β Secretion in Autoinflammatory Diseases: A Matter of Stress?

Carta S, Semino C, Sitia R, Rubartelli A.

Front Immunol. 2017 Apr 4;8:345. doi: 10.3389/fimmu.2017.00345. eCollection 2017.

9.

Structural basis of pH-dependent client binding by ERp44, a key regulator of protein secretion at the ER-Golgi interface.

Watanabe S, Harayama M, Kanemura S, Sitia R, Inaba K.

Proc Natl Acad Sci U S A. 2017 Apr 18;114(16):E3224-E3232. doi: 10.1073/pnas.1621426114. Epub 2017 Apr 3.

10.

Roles of N-glycans in the polymerization-dependent aggregation of mutant Ig-μ chains in the early secretory pathway.

Giannone C, Fagioli C, Valetti C, Sitia R, Anelli T.

Sci Rep. 2017 Feb 3;7:41815. doi: 10.1038/srep41815.

11.

Regulation of Calcium Fluxes by GPX8, a Type-II Transmembrane Peroxidase Enriched at the Mitochondria-Associated Endoplasmic Reticulum Membrane.

Yoboue ED, Rimessi A, Anelli T, Pinton P, Sitia R.

Antioxid Redox Signal. 2017 Sep 20;27(9):583-595. doi: 10.1089/ars.2016.6866. Epub 2017 Apr 17.

PMID:
28129698
12.

Assessing Heterogeneity of Osteolytic Lesions in Multiple Myeloma by ¹H HR-MAS NMR Metabolomics.

Tavel L, Fontana F, Garcia Manteiga JM, Mari S, Mariani E, Caneva E, Sitia R, Camnasio F, Marcatti M, Cenci S, Musco G.

Int J Mol Sci. 2016 Oct 31;17(11). pii: E1814.

13.

AQP8 transports NOX2-generated H2O2 across the plasma membrane to promote signaling in B cells.

Bertolotti M, Farinelli G, Galli M, Aiuti A, Sitia R.

J Leukoc Biol. 2016 Nov;100(5):1071-1079. Epub 2016 Jun 2.

PMID:
27256569
14.

Crystal Structure of the ERp44-Peroxiredoxin 4 Complex Reveals the Molecular Mechanisms of Thiol-Mediated Protein Retention.

Yang K, Li DF, Wang X, Liang J, Sitia R, Wang CC, Wang X.

Structure. 2016 Oct 4;24(10):1755-1765. doi: 10.1016/j.str.2016.08.002. Epub 2016 Sep 15.

15.

Stress Regulates Aquaporin-8 Permeability to Impact Cell Growth and Survival.

Medraño-Fernandez I, Bestetti S, Bertolotti M, Bienert GP, Bottino C, Laforenza U, Rubartelli A, Sitia R.

Antioxid Redox Signal. 2016 Jun 20;24(18):1031-44. doi: 10.1089/ars.2016.6636. Epub 2016 Apr 19.

16.

Transit of H2O2 across the endoplasmic reticulum membrane is not sluggish.

Appenzeller-Herzog C, Bánhegyi G, Bogeski I, Davies KJ, Delaunay-Moisan A, Forman HJ, Görlach A, Kietzmann T, Laurindo F, Margittai E, Meyer AJ, Riemer J, Rützler M, Simmen T, Sitia R, Toledano MB, Touw IP.

Free Radic Biol Med. 2016 May;94:157-60. doi: 10.1016/j.freeradbiomed.2016.02.030. Epub 2016 Feb 27.

PMID:
26928585
17.

Aberrant disulphide bonding contributes to the ER retention of alpha1-antitrypsin deficiency variants.

Ronzoni R, Berardelli R, Medicina D, Sitia R, Gooptu B, Fra AM.

Hum Mol Genet. 2016 Feb 15;25(4):642-50. doi: 10.1093/hmg/ddv501. Epub 2015 Dec 8.

PMID:
26647313
18.

Biochemical nature of Russell Bodies.

Mossuto MF, Ami D, Anelli T, Fagioli C, Doglia SM, Sitia R.

Sci Rep. 2015 Jul 30;5:12585. doi: 10.1038/srep12585.

19.

Proteostasis and "redoxtasis" in the secretory pathway: Tales of tails from ERp44 and immunoglobulins.

Anelli T, Sannino S, Sitia R.

Free Radic Biol Med. 2015 Jun;83:323-30. doi: 10.1016/j.freeradbiomed.2015.02.020. Epub 2015 Mar 2. Review.

PMID:
25744412
20.

Sialylation of N-linked glycans influences the immunomodulatory effects of IgM on T cells.

Colucci M, Stöckmann H, Butera A, Masotti A, Baldassarre A, Giorda E, Petrini S, Rudd PM, Sitia R, Emma F, Vivarelli M.

J Immunol. 2015 Jan 1;194(1):151-7. doi: 10.4049/jimmunol.1402025. Epub 2014 Nov 24.

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