Format

Send to

Choose Destination

See 1 citation found using an alternative search:

Nano Lett. 2012 Mar 14;12(3):1722-8. doi: 10.1021/nl300372a. Epub 2012 Feb 24.

Electronic barcoding of a viral gene at the single-molecule level.

Author information

1
Department of Biomedical Engineering, Boston University, Boston, Massachusetts 02215, USA.

Abstract

A new single-molecule approach for rapid and purely electronic discrimination among similar genes is presented. Combining solid-state nanopores and γ-modified synthetic peptide nucleic acid probes, we accurately barcode genes by counting the number of probes attached to each gene and measuring their relative spacing. We illustrate our method by sensing individual genes from two highly similar human immunodeficiency virus subtypes, demonstrating feasibility of a novel, single-molecule diagnostic platform for rapid pathogen classification.

PMID:
22352964
PMCID:
PMC3572535
DOI:
10.1021/nl300372a
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for American Chemical Society Icon for PubMed Central
Loading ...
Support Center