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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1969 1
1977 1
1978 1
1979 1
1980 1
1983 1
1996 2
1997 1
1998 6
1999 6
2000 5
2001 1
2002 2
2006 1
2008 1
2016 2
2018 1
2019 5
2020 2
2021 1
2024 0

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40 results

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Page 1
Discovery of MK-4688: an Efficient Inhibitor of the HDM2-p53 Protein-Protein Interaction.
Reutershan MH, Machacek MR, Altman MD, Bogen S, Cai M, Cammarano C, Chen D, Christopher M, Cryan J, Daublain P, Fradera X, Geda P, Goldenblatt P, Hill AD, Kemper RA, Kutilek V, Li C, Martinez M, McCoy M, Nair L, Pan W, Thompson CF, Scapin G, Shizuka M, Spatz ML, Steinhuebel D, Sun B, Voss ME, Wang X, Yang L, Yeh TC, Dussault I, Marshall CG, Trotter BW. Reutershan MH, et al. Among authors: shizuka m. J Med Chem. 2021 Nov 11;64(21):16213-16241. doi: 10.1021/acs.jmedchem.1c01524. Epub 2021 Oct 29. J Med Chem. 2021. PMID: 34714078
Synthesis of Highly Potent N-10 Amino-Linked DNA-Alkylating Indolinobenzodiazepine Antibody-Drug Conjugates (ADCs).
Archer KE, Reid EE, Shizuka M, Woods J, Harris L, Maloney EK, Bartle LM, Ab O, Wilhelm A, Setiady Y, Ponte JF, Singh R, Keating TA, Chari RVJ, Miller ML. Archer KE, et al. Among authors: shizuka m. ACS Med Chem Lett. 2019 Jul 22;10(8):1211-1215. doi: 10.1021/acsmedchemlett.9b00254. eCollection 2019 Aug 8. ACS Med Chem Lett. 2019. PMID: 31413807 Free PMC article.
Effect of Linker Stereochemistry on the Activity of Indolinobenzodiazepine Containing Antibody-Drug Conjugates (ADCs).
Reid EE, Archer KE, Shizuka M, Wilhelm A, Yoder NC, Bai C, Fishkin NE, Harris L, Maloney EK, Salomon P, Hong E, Wu R, Ab O, Jin S, Lai KC, Sikka S, Chari RVJ, Miller ML. Reid EE, et al. Among authors: shizuka m. ACS Med Chem Lett. 2019 Jul 10;10(8):1193-1197. doi: 10.1021/acsmedchemlett.9b00240. eCollection 2019 Aug 8. ACS Med Chem Lett. 2019. PMID: 31413805 Free PMC article.
A DNA-Interacting Payload Designed to Eliminate Cross-Linking Improves the Therapeutic Index of Antibody-Drug Conjugates (ADCs).
Miller ML, Shizuka M, Wilhelm A, Salomon P, Reid EE, Lanieri L, Sikka S, Maloney EK, Harvey L, Qiu Q, Archer KE, Bai C, Vitharana D, Harris L, Singh R, Ponte JF, Yoder NC, Kovtun Y, Lai KC, Ab O, Pinkas J, Keating TA, Chari RVJ. Miller ML, et al. Among authors: shizuka m. Mol Cancer Ther. 2018 Mar;17(3):650-660. doi: 10.1158/1535-7163.MCT-17-0940. Epub 2018 Feb 13. Mol Cancer Ther. 2018. PMID: 29440292
Site-Specific Conjugation of the Indolinobenzodiazepine DGN549 to Antibodies Affords Antibody-Drug Conjugates with an Improved Therapeutic Index as Compared with Lysine Conjugation.
Bai C, Reid EE, Wilhelm A, Shizuka M, Maloney EK, Laleau R, Harvey L, Archer KE, Vitharana D, Adams S, Kovtun Y, Miller ML, Chari R, Keating TA, Yoder NC. Bai C, et al. Among authors: shizuka m. Bioconjug Chem. 2020 Jan 15;31(1):93-103. doi: 10.1021/acs.bioconjchem.9b00777. Epub 2019 Dec 10. Bioconjug Chem. 2020. PMID: 31747250 Free article.
Mutational spectrum of the CHAC gene in patients with chorea-acanthocytosis.
Dobson-Stone C, Danek A, Rampoldi L, Hardie RJ, Chalmers RM, Wood NW, Bohlega S, Dotti MT, Federico A, Shizuka M, Tanaka M, Watanabe M, Ikeda Y, Brin M, Goldfarb LG, Karp BI, Mohiddin S, Fananapazir L, Storch A, Fryer AE, Maddison P, Sibon I, Trevisol-Bittencourt PC, Singer C, Caballero IR, Aasly JO, Schmierer K, Dengler R, Hiersemenzel LP, Zeviani M, Meiner V, Lossos A, Johnson S, Mercado FC, Sorrentino G, Dupré N, Rouleau GA, Volkmann J, Arpa J, Lees A, Geraud G, Chouinard S, Németh A, Monaco AP. Dobson-Stone C, et al. Among authors: shizuka m. Eur J Hum Genet. 2002 Nov;10(11):773-81. doi: 10.1038/sj.ejhg.5200866. Eur J Hum Genet. 2002. PMID: 12404112
40 results