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Sensitivity of HIV-1 to entry inhibitors correlates with envelope/coreceptor affinity, receptor density, and fusion kinetics.
Reeves JD, Gallo SA, Ahmad N, Miamidian JL, Harvey PE, Sharron M, Pohlmann S, Sfakianos JN, Derdeyn CA, Blumenthal R, Hunter E, Doms RW. Reeves JD, et al. Among authors: sfakianos jn. Proc Natl Acad Sci U S A. 2002 Dec 10;99(25):16249-54. doi: 10.1073/pnas.252469399. Epub 2002 Nov 20. Proc Natl Acad Sci U S A. 2002. PMID: 12444251 Free PMC article.
Sensitivity of human immunodeficiency virus type 1 to fusion inhibitors targeted to the gp41 first heptad repeat involves distinct regions of gp41 and is consistently modulated by gp120 interactions with the coreceptor.
Derdeyn CA, Decker JM, Sfakianos JN, Zhang Z, O'Brien WA, Ratner L, Shaw GM, Hunter E. Derdeyn CA, et al. Among authors: sfakianos jn. J Virol. 2001 Sep;75(18):8605-14. doi: 10.1128/jvi.75.18.8605-8614.2001. J Virol. 2001. PMID: 11507206 Free PMC article.
Unique mutational patterns in the envelope alpha 2 amphipathic helix and acquisition of length in gp120 hypervariable domains are associated with resistance to autologous neutralization of subtype C human immunodeficiency virus type 1.
Rong R, Gnanakaran S, Decker JM, Bibollet-Ruche F, Taylor J, Sfakianos JN, Mokili JL, Muldoon M, Mulenga J, Allen S, Hahn BH, Shaw GM, Blackwell JL, Korber BT, Hunter E, Derdeyn CA. Rong R, et al. Among authors: sfakianos jn. J Virol. 2007 Jun;81(11):5658-68. doi: 10.1128/JVI.00257-07. Epub 2007 Mar 14. J Virol. 2007. PMID: 17360739 Free PMC article.