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PLoS Biol. 2016 Mar 24;14(3):e1002412. doi: 10.1371/journal.pbio.1002412. eCollection 2016 Mar.

Separable Roles for a Caenorhabditis elegans RMI1 Homolog in Promoting and Antagonizing Meiotic Crossovers Ensure Faithful Chromosome Inheritance.

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Department of Chromosome Biology, Max F. Perutz Laboratories, Vienna Bio Center, University of Vienna, Vienna, Austria.
Departments of Developmental Biology and Genetics, Stanford University School of Medicine, Stanford, California, United States of America.
Center for Integrative Bioinformatics Vienna (CIBIV), Max F. Perutz Laboratories, Vienna Bio Center, University of Vienna and Medical University of Vienna, Vienna, Austria.
Bioinformatics and Computational Biology, Faculty of Computer Science, University of Vienna, Austria.


During the first meiotic division, crossovers (COs) between homologous chromosomes ensure their correct segregation. COs are produced by homologous recombination (HR)-mediated repair of programmed DNA double strand breaks (DSBs). As more DSBs are induced than COs, mechanisms are required to establish a regulated number of COs and to repair remaining intermediates as non-crossovers (NCOs). We show that the Caenorhabditis elegans RMI1 homolog-1 (RMH-1) functions during meiosis to promote both CO and NCO HR at appropriate chromosomal sites. RMH-1 accumulates at CO sites, dependent on known pro-CO factors, and acts to promote CO designation and enforce the CO outcome of HR-intermediate resolution. RMH-1 also localizes at NCO sites and functions in parallel with SMC-5 to antagonize excess HR-based connections between chromosomes. Moreover, RMH-1 also has a major role in channeling DSBs into an NCO HR outcome near the centers of chromosomes, thereby ensuring that COs form predominantly at off-center positions.

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