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Semin Immunopathol. 2007 Nov;29(4):337-53. Epub 2007 Oct 18.

B cells in glomerulonephritis: focus on lupus nephritis.

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Division of Renal Medicine, Department of Medicine and Cambridge Institute for Medical Research, University of Cambridge, Lab 5.15, Box 139 Addenbrooke's Hospital, Cambridge, CB2 2XY, UK.


The production of pathogenic antibody has been traditionally viewed as the principle contribution of B cells to the pathogenesis of immune-mediated glomerulonephritis. However, it is increasingly appreciated that B cells play a much broader role in such diseases, functioning as antigen-presenting cells, regulators of T cells, dendritic cells, and macrophages and orchestrators of local lymphatic expansion. In this review, we provide an overview of basic B cell biology and consider the evidence implicating B cells in one of the archetypal immune-mediated glomerulonephritides, lupus nephritis.

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