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Semin Immunopathol. 2007 Nov;29(4):337-53. Epub 2007 Oct 18.

B cells in glomerulonephritis: focus on lupus nephritis.

Author information

1
Division of Renal Medicine, Department of Medicine and Cambridge Institute for Medical Research, University of Cambridge, Lab 5.15, Box 139 Addenbrooke's Hospital, Cambridge, CB2 2XY, UK. mrc38@cam.ac.uk

Abstract

The production of pathogenic antibody has been traditionally viewed as the principle contribution of B cells to the pathogenesis of immune-mediated glomerulonephritis. However, it is increasingly appreciated that B cells play a much broader role in such diseases, functioning as antigen-presenting cells, regulators of T cells, dendritic cells, and macrophages and orchestrators of local lymphatic expansion. In this review, we provide an overview of basic B cell biology and consider the evidence implicating B cells in one of the archetypal immune-mediated glomerulonephritides, lupus nephritis.

PMID:
17943287
DOI:
10.1007/s00281-007-0092-1
[Indexed for MEDLINE]

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