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Nat Rev Immunol. 2016 Jan;16(1):35-50. doi: 10.1038/nri.2015.8.

Self-regulation and cross-regulation of pattern-recognition receptor signalling in health and disease.

Cao X1,2.

Author information

1
National Key Laboratory of Medical Molecular Biology &Department of Immunology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, Beijing 100005, China.
2
National Key Laboratory of Medical Immunology &Institute of Immunology, Second Military Medical University, Shanghai 200433, China.

Abstract

In the initiation of innate immune responses against pathogens, pattern-recognition receptors (PRRs) have an essential role in recognizing specific components of microorganisms and triggering responses that eliminate the invading microorganisms. However, inappropriate activation of PRRs can lead to prolonged inflammation and even to autoimmune and inflammatory diseases. Thus, PRR-triggered responses are regulated through the degradation or translocation of the innate receptors themselves and through the involvement of intracellular regulators or amplifiers. In addition, a complex interplay between PRRs and/or other immune pathways finely tunes the outcome of host immune defence responses. In this Review, I describe many of the numerous distinct mechanisms for the self-regulation and cross-regulation of innate immune receptor signalling.

PMID:
26711677
DOI:
10.1038/nri.2015.8
[Indexed for MEDLINE]

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