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Trends Microbiol. 2014 Aug;22(8):446-55. doi: 10.1016/j.tim.2014.04.001. Epub 2014 May 2.

Selective packaging of the influenza A genome and consequences for genetic reassortment.

Author information

1
Architecture et Réactivité de l'ARN, Université de Strasbourg, Centre National de Recherche Scientifique (CNRS), Institut de Biologie Moléculaire et Cellulaire (IBMC), 15 rue René Descartes, 67084 Strasbourg, France.
2
Virologie et Pathologie Humaine, Université Lyon 1, EA4610, Faculté de Médecine RTH Laennec, 69008 Lyon, France; VirNext, Université Lyon 1, EA4610, Faculté de Médecine RTH Laennec, 69008 Lyon, France.
3
Architecture et Réactivité de l'ARN, Université de Strasbourg, Centre National de Recherche Scientifique (CNRS), Institut de Biologie Moléculaire et Cellulaire (IBMC), 15 rue René Descartes, 67084 Strasbourg, France. Electronic address: r.marquet@ibmc-cnrs.unistra.fr.

Abstract

Influenza A viruses package their segmented RNA genome in a selective manner. Electron tomography, biochemical assays, and replication assays of viruses produced by reverse genetics recently unveiled molecular details of this mechanism, whereby different influenza viral strains form different and unique networks of direct intermolecular RNA-RNA interactions. Together with detailed views of the three-dimensional structure of the viral ribonucleoparticles, these recent advances help us understand the rules that govern genome packaging. They also have deep implications for the genetic reassortment processes, which are responsible for devastating pandemics.

KEYWORDS:

RNA–RNA interactions; genetic reassortment; influenza A virus; packaging; supramolecular complex

PMID:
24798745
DOI:
10.1016/j.tim.2014.04.001
[Indexed for MEDLINE]

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