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Targeting Mitochondrial Proline Dehydrogenase with a Suicide Inhibitor to Exploit Synthetic Lethal Interactions with p53 Upregulation and Glutaminase Inhibition.

Scott GK, Yau C, Becker BC, Khateeb S, Mahoney S, Jensen MB, Hann B, Cowen BJ, Pegan SD, Benz CC.

Mol Cancer Ther. 2019 Jun 12. doi: 10.1158/1535-7163.MCT-18-1323. [Epub ahead of print]


ERpS294 is a biomarker of ligand or mutational ERα activation and a breast cancer target for CDK2 inhibition.

Scott GK, Chu D, Kaur R, Malato J, Rothschild DE, Frazier K, Eppenberger-Castori S, Hann B, Park BH, Benz CC.

Oncotarget. 2016 Oct 18;8(48):83432-83445. doi: 10.18632/oncotarget.12735. eCollection 2017 Oct 13.


Sources of superoxide/H2O2 during mitochondrial proline oxidation.

Goncalves RL, Rothschild DE, Quinlan CL, Scott GK, Benz CC, Brand MD.

Redox Biol. 2014 Jul 18;2:901-9. doi: 10.1016/j.redox.2014.07.003. eCollection 2014.


RPL24: a potential therapeutic target whose depletion or acetylation inhibits polysome assembly and cancer cell growth.

Wilson-Edell KA, Kehasse A, Scott GK, Yau C, Rothschild DE, Schilling B, Gabriel BS, Yevtushenko MA, Hanson IM, Held JM, Gibson BW, Benz CC.

Oncotarget. 2014 Jul 15;5(13):5165-76.


FOXP3-positive regulatory T lymphocytes and epithelial FOXP3 expression in synchronous normal, ductal carcinoma in situ, and invasive cancer of the breast.

Lal A, Chan L, Devries S, Chin K, Scott GK, Benz CC, Chen YY, Waldman FM, Hwang ES.

Breast Cancer Res Treat. 2013 Jun;139(2):381-90. doi: 10.1007/s10549-013-2556-4. Epub 2013 May 28.


Comprehensive molecular portraits of human breast tumours.

Cancer Genome Atlas Network.

Nature. 2012 Oct 4;490(7418):61-70. doi: 10.1038/nature11412. Epub 2012 Sep 23.


Comprehensive genomic characterization of squamous cell lung cancers.

Cancer Genome Atlas Research Network.

Nature. 2012 Sep 27;489(7417):519-25. doi: 10.1038/nature11404. Epub 2012 Sep 9. Erratum in: Nature. 2012 Nov 8;491(7423):288. Rogers, Kristen [corrected to Rodgers, Kristen].


Comprehensive molecular characterization of human colon and rectal cancer.

Cancer Genome Atlas Network.

Nature. 2012 Jul 18;487(7407):330-7. doi: 10.1038/nature11252.


Ligand binding promotes CDK-dependent phosphorylation of ER-alpha on hinge serine 294 but inhibits ligand-independent phosphorylation of serine 305.

Held JM, Britton DJ, Scott GK, Lee EL, Schilling B, Baldwin MA, Gibson BW, Benz CC.

Mol Cancer Res. 2012 Aug;10(8):1120-32. doi: 10.1158/1541-7786.MCR-12-0099. Epub 2012 Jun 5.


MicroRNAs miR-146a/b negatively modulate the senescence-associated inflammatory mediators IL-6 and IL-8.

Bhaumik D, Scott GK, Schokrpur S, Patil CK, Orjalo AV, Rodier F, Lithgow GJ, Campisi J.

Aging (Albany NY). 2009 Apr;1(4):402-11.


Cell surface-bound IL-1alpha is an upstream regulator of the senescence-associated IL-6/IL-8 cytokine network.

Orjalo AV, Bhaumik D, Gengler BK, Scott GK, Campisi J.

Proc Natl Acad Sci U S A. 2009 Oct 6;106(40):17031-6. doi: 10.1073/pnas.0905299106. Epub 2009 Sep 28.


Protein acetylation and histone deacetylase expression associated with malignant breast cancer progression.

Suzuki J, Chen YY, Scott GK, Devries S, Chin K, Benz CC, Waldman FM, Hwang ES.

Clin Cancer Res. 2009 May 1;15(9):3163-71. doi: 10.1158/1078-0432.CCR-08-2319. Epub 2009 Apr 21.


Breast cancer metastasis suppressor 1 up-regulates miR-146, which suppresses breast cancer metastasis.

Hurst DR, Edmonds MD, Scott GK, Benz CC, Vaidya KS, Welch DR.

Cancer Res. 2009 Feb 15;69(4):1279-83. doi: 10.1158/0008-5472.CAN-08-3559. Epub 2009 Feb 3.


Systematic mapping of posttranslational modifications in human estrogen receptor-alpha with emphasis on novel phosphorylation sites.

Atsriku C, Britton DJ, Held JM, Schilling B, Scott GK, Gibson BW, Benz CC, Baldwin MA.

Mol Cell Proteomics. 2009 Mar;8(3):467-80. doi: 10.1074/mcp.M800282-MCP200. Epub 2008 Nov 3.


Destabilization of ERBB2 transcripts by targeting 3' untranslated region messenger RNA associated HuR and histone deacetylase-6.

Scott GK, Marx C, Berger CE, Saunders LR, Verdin E, Schäfer S, Jung M, Benz CC.

Mol Cancer Res. 2008 Jul;6(7):1250-8. doi: 10.1158/1541-7786.MCR-07-2110.


Expression of microRNA-146 suppresses NF-kappaB activity with reduction of metastatic potential in breast cancer cells.

Bhaumik D, Scott GK, Schokrpur S, Patil CK, Campisi J, Benz CC.

Oncogene. 2008 Sep 18;27(42):5643-7. doi: 10.1038/onc.2008.171. Epub 2008 May 26.


A novel serine phosphorylation site detected in the N-terminal domain of estrogen receptor isolated from human breast cancer cells.

Britton DJ, Scott GK, Schilling B, Atsriku C, Held JM, Gibson BW, Benz CC, Baldwin MA.

J Am Soc Mass Spectrom. 2008 May;19(5):729-40. doi: 10.1016/j.jasms.2008.02.008. Epub 2008 Mar 4.


Proteasome-regulated ERBB2 and estrogen receptor pathways in breast cancer.

Marx C, Yau C, Banwait S, Zhou Y, Scott GK, Hann B, Park JW, Benz CC.

Mol Pharmacol. 2007 Jun;71(6):1525-34. Epub 2007 Mar 28.


Quantification of cysteine oxidation in human estrogen receptor by mass spectrometry.

Atsriku C, Benz CC, Scott GK, Gibson BW, Baldwin MA.

Anal Chem. 2007 Apr 15;79(8):3083-90. Epub 2007 Mar 21.


Novel pathways associated with quinone-induced stress in breast cancer cells.

Benz CC, Atsriku C, Yau C, Britton D, Schilling B, Gibson BW, Baldwin MA, Scott GK.

Drug Metab Rev. 2006;38(4):601-13. Review.


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