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See 1 citation in Sci Rep 2016:

Sci Rep. 2016 Nov 22;6:37354. doi: 10.1038/srep37354.

Circulating long-non coding RNAs as biomarkers of left ventricular diastolic function and remodelling in patients with well-controlled type 2 diabetes.

Author information

1
Cardiovascular Research Center (CSIC-ICCC), Biomedical Research Institute Sant Pau (IIB Sant Pau), Barcelona, Spain.
2
Institute of Molecular and Translational Therapeutic Strategies (IMTTS), IFB-Tx, Hannover Medical School, Hannover, Germany.
3
Department of Medicine, University of Cádiz, Cádiz, Spain.
4
Department of Radiology, Leiden University Medical Center, Leiden, The Netherlands.
5
Department of Medicine, Kantonsspital Baden AG, Baden, Switzerland.
6
Department of Internal Medicine, University Medical Center Nijmegen, Nijmegen, The Netherlands.
7
Excellence Cluster REBIRTH, Hannover Medical School, Hannover, Germany.
8
National Heart and Lung Institute, Imperial College, London, UK.

Abstract

Contractile dysfunction is underdiagnosed in early stages of diabetic cardiomyopathy. We evaluated the potential of circulating long non-coding RNAs (lncRNAs) as biomarkers of subclinical cardiac abnormalities in type 2 diabetes. Forty-eight men with well-controlled type 2 diabetes and 12 healthy age-matched volunteers were enrolled in the study. Left ventricular (LV) parameters were measured by magnetic resonance imaging. A panel of lncRNAs was quantified in serum by RT-qPCR. No differences in expression levels of lncRNAs were observed between type 2 diabetes patients and healthy volunteers. In patients with type 2 diabetes, long intergenic non-coding RNA predicting cardiac remodeling (LIPCAR) was inversely associated with diastolic function, measured as E/A peak flow (P < 0.050 for all linear models). LIPCAR was positively associated with grade I diastolic dysfunction (P < 0.050 for all logistic models). Myocardial infarction-associated transcript (MIAT) and smooth muscle and endothelial cell-enriched migration/differentiation-associated long noncoding RNA (SENCR) were directly associated with LV mass to LV end-diastolic volume ratio, a marker of cardiac remodelling (P < 0.050 for all linear models). These findings were validated in a sample of 30 patients with well-controlled type 2 diabetes. LncRNAs are independent predictors of diastolic function and remodelling in patients with type 2 diabetes.

PMID:
27874027
PMCID:
PMC5118808
DOI:
10.1038/srep37354
[Indexed for MEDLINE]
Free PMC Article

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