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Chest. 2006 Apr;129(4):988-94.

Real-time electromagnetic navigation bronchoscopy to peripheral lung lesions using overlaid CT images: the first human study.

Author information

1
Pulmonary Institute, Tel Aviv Sourasky Medical Center, Weizman Stt 6, Tel Aviv 64239, Israel. Schwarz@tasmc.health.gov.il

Abstract

STUDY OBJECTIVES:

To characterize the feasibility, accuracy, and safety of the superDimension/Bronchus system (SDBS) [superDimension, Ltd; Hertzliya, Israel] in navigating to previously unreachable peripheral lung lesions and obtaining biopsy specimens.

DESIGN:

Open-label, prospective, controlled clinical study.

SETTING:

Pulmonary institute of a university-affiliated municipal hospital.

PATIENTS:

Thirteen adult candidates for nonemergency bronchoscopy who gave informed consent to participate.

INTERVENTIONS:

The patients underwent flexible bronchoscopy using the SDBS, which is based on real-time CT-guided electromagnetic navigation and is capable of reaching peripheral lung masses beyond the reach of the bronchoscope. A position sensor was used to navigate to and sample the various target lesions for biopsy.

MEASUREMENTS AND RESULTS:

Three-dimensional chest CT was followed by SDBS methodology for marking anatomic landmarks and the target lesion on a virtual bronchoscopy screen and for sampling the lesion. The SDBS assisted in obtaining positive biopsy diagnoses in 9 of 13 cases (69%), with an average navigation accuracy of 5.7 mm. There were no SDBS-related adverse events.

CONCLUSIONS:

The SDBS is safe and effective in navigating to peripheral lung lesions located beyond the optic limits of a standard flexible bronchoscope.

PMID:
16608948
DOI:
10.1378/chest.129.4.988
[Indexed for MEDLINE]

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