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Page 1
Design and optimization of highly-selective fungal CYP51 inhibitors.
Hoekstra WJ, Garvey EP, Moore WR, Rafferty SW, Yates CM, Schotzinger RJ. Hoekstra WJ, et al. Among authors: schotzinger rj. Bioorg Med Chem Lett. 2014 Aug 1;24(15):3455-8. doi: 10.1016/j.bmcl.2014.05.068. Epub 2014 Jun 9. Bioorg Med Chem Lett. 2014. PMID: 24948565
VT-1161 Protects Immunosuppressed Mice from Rhizopus arrhizus var. arrhizus Infection.
Gebremariam T, Wiederhold NP, Fothergill AW, Garvey EP, Hoekstra WJ, Schotzinger RJ, Patterson TF, Filler SG, Ibrahim AS. Gebremariam T, et al. Among authors: schotzinger rj. Antimicrob Agents Chemother. 2015 Dec;59(12):7815-7. doi: 10.1128/AAC.01437-15. Epub 2015 Sep 14. Antimicrob Agents Chemother. 2015. PMID: 26369977 Free PMC article.
Prophylactic Treatment with VT-1161 Protects Immunosuppressed Mice from Rhizopus arrhizus var. arrhizus Infection.
Gebremariam T, Alkhazraji S, Lin L, Wiederhold NP, Garvey EP, Hoekstra WJ, Schotzinger RJ, Patterson TF, Filler SG, Ibrahim AS. Gebremariam T, et al. Among authors: schotzinger rj. Antimicrob Agents Chemother. 2017 Aug 24;61(9):e00390-17. doi: 10.1128/AAC.00390-17. Print 2017 Sep. Antimicrob Agents Chemother. 2017. PMID: 28652241 Free PMC article.
The Fungal Cyp51 Inhibitor VT-1129 Is Efficacious in an Experimental Model of Cryptococcal Meningitis.
Wiederhold NP, Najvar LK, Garvey EP, Brand SR, Xu X, Ottinger EA, Alimardanov A, Cradock J, Behnke M, Hoekstra WJ, Schotzinger RJ, Jaramillo R, Olivo M, Kirkpatrick WR, Patterson TF. Wiederhold NP, et al. Among authors: schotzinger rj. Antimicrob Agents Chemother. 2018 Aug 27;62(9):e01071-18. doi: 10.1128/AAC.01071-18. Print 2018 Sep. Antimicrob Agents Chemother. 2018. PMID: 29987152 Free PMC article.
The Fungal Cyp51-Specific Inhibitor VT-1598 Demonstrates In Vitro and In Vivo Activity against Candida auris.
Wiederhold NP, Lockhart SR, Najvar LK, Berkow EL, Jaramillo R, Olivo M, Garvey EP, Yates CM, Schotzinger RJ, Catano G, Patterson TF. Wiederhold NP, et al. Among authors: schotzinger rj. Antimicrob Agents Chemother. 2019 Feb 26;63(3):e02233-18. doi: 10.1128/AAC.02233-18. Print 2019 Mar. Antimicrob Agents Chemother. 2019. PMID: 30530603 Free PMC article.
35 results