Format

Send to

Choose Destination

See 1 citation found using an alternative search:

See comment in PubMed Commons below
Br J Clin Pharmacol. 2011 Dec;72(6):879-97. doi: 10.1111/j.1365-2125.2011.04071.x.

Applications of stable isotopes in clinical pharmacology.

Author information

  • 1Department of Hospital and Clinical Pharmacy, University Medical Center Groningen, The Netherlands. reinout.schellekens@kpnplanet.nl

Erratum in

  • Br J Clin Pharmacol. 2013 Apr;75(4):1171.

Abstract

This review aims to present an overview of the application of stable isotope technology in clinical pharmacology. Three main categories of stable isotope technology can be distinguished in clinical pharmacology. Firstly, it is applied in the assessment of drug pharmacology to determine the pharmacokinetic profile or mode of action of a drug substance. Secondly, stable isotopes may be used for the assessment of drug products or drug delivery systems by determination of parameters such as the bioavailability or the release profile. Thirdly, patients may be assessed in relation to patient-specific drug treatment; this concept is often called personalized medicine. In this article, the application of stable isotope technology in the aforementioned three areas is reviewed, with emphasis on developments over the past 25 years. The applications are illustrated with examples from clinical studies in humans.

PMID:
21801197
PMCID:
PMC3244634
DOI:
10.1111/j.1365-2125.2011.04071.x
[PubMed - indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Wiley Icon for PubMed Central
    Loading ...
    Support Center