Format
Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 20 of 83

1.

The multi-site docking protein Grb2-associated binder 1 (Gab1) enhances interleukin-6-induced MAPK-pathway activation in an SHP2-, Grb2-, and time-dependent manner.

Bongartz H, Gille K, Hessenkemper W, Mandel K, Lewitzky M, Feller SM, Schaper F.

Cell Commun Signal. 2019 Oct 24;17(1):135. doi: 10.1186/s12964-019-0451-2.

2.

Intragenic regulation of SOCS3 isoforms.

Klepsch O, Namer LS, Köhler N, Kaempfer R, Dittrich A, Schaper F.

Cell Commun Signal. 2019 Jun 25;17(1):70. doi: 10.1186/s12964-019-0379-6.

3.

Response to IL-6 trans- and IL-6 classic signalling is determined by the ratio of the IL-6 receptor α to gp130 expression: fusing experimental insights and dynamic modelling.

Reeh H, Rudolph N, Billing U, Christen H, Streif S, Bullinger E, Schliemann-Bullinger M, Findeisen R, Schaper F, Huber HJ, Dittrich A.

Cell Commun Signal. 2019 May 17;17(1):46. doi: 10.1186/s12964-019-0356-0.

4.

Robustness and Information Transfer within IL-6-induced JAK/STAT Signalling.

Billing U, Jetka T, Nortmann L, Wundrack N, Komorowski M, Waldherr S, Schaper F, Dittrich A.

Commun Biol. 2019 Jan 18;2:27. doi: 10.1038/s42003-018-0259-4. eCollection 2019.

5.

Designing optimal experiments to discriminate interaction graph models.

Thiele S, Heise S, Hessenkemper W, Bongartz H, Fensky M, Schaper F, Klamt S.

IEEE/ACM Trans Comput Biol Bioinform. 2018 Mar 15. doi: 10.1109/TCBB.2018.2812184. [Epub ahead of print]

PMID:
29993657
6.

Interaction of suppressor of cytokine signalling 3 with cavin-1 links SOCS3 function and cavin-1 stability.

Williams JJL, Alotaiq N, Mullen W, Burchmore R, Liu L, Baillie GS, Schaper F, Pilch PF, Palmer TM.

Nat Commun. 2018 Jan 12;9(1):168. doi: 10.1038/s41467-017-02585-y.

7.

The multi-site docking protein Gab1 is constitutively phosphorylated independent from its recruitment to the plasma membrane in Jak2-V617F-positive cells and mediates proliferation of human erythroleukaemia cells.

Bongartz H, Hessenkemper W, Müller C, Fensky M, Fritsch J, Mandel K, Behrmann I, Haan C, Fischer T, Feller SM, Schaper F.

Cell Signal. 2017 Jul;35:37-47. doi: 10.1016/j.cellsig.2017.03.021. Epub 2017 Mar 30.

PMID:
28365441
8.

Interleukin-6 influences stress-signalling by reducing the expression of the mTOR-inhibitor REDD1 in a STAT3-dependent manner.

Pinno J, Bongartz H, Klepsch O, Wundrack N, Poli V, Schaper F, Dittrich A.

Cell Signal. 2016 Aug;28(8):907-16. doi: 10.1016/j.cellsig.2016.04.004. Epub 2016 Apr 16.

9.

"Family reunion"--A structured view on the composition of the receptor complexes of interleukin-6-type and interleukin-12-type cytokines.

Rose-John S, Scheller J, Schaper F.

Cytokine Growth Factor Rev. 2015 Oct;26(5):471-4. doi: 10.1016/j.cytogfr.2015.07.011. Epub 2015 Jul 6. No abstract available.

PMID:
26235233
10.

Interleukin-6: Biology, signaling and strategies of blockade.

Schaper F, Rose-John S.

Cytokine Growth Factor Rev. 2015 Oct;26(5):475-87. doi: 10.1016/j.cytogfr.2015.07.004. Epub 2015 Jul 4. Review.

PMID:
26189695
11.

Systems biology of IL-6, IL-12 family cytokines.

Dittrich A, Hessenkemper W, Schaper F.

Cytokine Growth Factor Rev. 2015 Oct;26(5):595-602. doi: 10.1016/j.cytogfr.2015.07.002. Epub 2015 Jul 4. Review.

PMID:
26187858
12.

MAPK-induced Gab1 translocation to the plasma membrane depends on a regulated intramolecular switch.

Wolf A, Eulenfeld R, Bongartz H, Hessenkemper W, Simister PC, Lievens S, Tavernier J, Feller SM, Schaper F.

Cell Signal. 2015 Feb;27(2):340-52. doi: 10.1016/j.cellsig.2014.11.017. Epub 2014 Nov 25.

PMID:
25460044
13.

JAK2-V617F-induced MAPK activity is regulated by PI3K and acts synergistically with PI3K on the proliferation of JAK2-V617F-positive cells.

Wolf A, Eulenfeld R, Gäbler K, Rolvering C, Haan S, Behrmann I, Denecke B, Haan C, Schaper F.

JAKSTAT. 2013 Jul 1;2(3):e24574. doi: 10.4161/jkst.24574. Epub 2013 Apr 8.

14.

Protein tyrosine phosphatase SHP2/PTPN11 mistargeting as a consequence of SH2-domain point mutations associated with Noonan Syndrome and leukemia.

Müller PJ, Rigbolt KT, Paterok D, Piehler J, Vanselow J, Lasonder E, Andersen JS, Schaper F, Sobota RM.

J Proteomics. 2013 Jun 12;84:132-47. doi: 10.1016/j.jprot.2013.04.005. Epub 2013 Apr 11.

PMID:
23584145
15.

JAK/STAT signalling--an executable model assembled from molecule-centred modules demonstrating a module-oriented database concept for systems and synthetic biology.

Blätke MA, Dittrich A, Rohr C, Heiner M, Schaper F, Marwan W.

Mol Biosyst. 2013 Jun;9(6):1290-307. doi: 10.1039/c3mb25593j. Epub 2013 Feb 26.

PMID:
23443149
16.

mTORC1 inhibition restricts inflammation-associated gastrointestinal tumorigenesis in mice.

Thiem S, Pierce TP, Palmieri M, Putoczki TL, Buchert M, Preaudet A, Farid RO, Love C, Catimel B, Lei Z, Rozen S, Gopalakrishnan V, Schaper F, Hallek M, Boussioutas A, Tan P, Jarnicki A, Ernst M.

J Clin Invest. 2013 Feb;123(2):767-81. doi: 10.1172/JCI65086. Epub 2013 Jan 16.

17.

Determination of protein turnover rates in the JAK/STAT pathway using a radioactive pulse-chase approach.

Dittrich A, Siewert E, Schaper F.

Methods Mol Biol. 2013;967:69-80. doi: 10.1007/978-1-62703-242-1_5.

PMID:
23296722
18.

Model-driven experimental analysis of the function of SHP-2 in IL-6-induced Jak/STAT signaling.

Dittrich A, Quaiser T, Khouri C, Görtz D, Mönnigmann M, Schaper F.

Mol Biosyst. 2012 Aug;8(8):2119-34. doi: 10.1039/c2mb05488d. Epub 2012 Jun 19.

PMID:
22711165
19.

Plasticity and cross-talk of interleukin 6-type cytokines.

Garbers C, Hermanns HM, Schaper F, Müller-Newen G, Grötzinger J, Rose-John S, Scheller J.

Cytokine Growth Factor Rev. 2012 Jun;23(3):85-97. doi: 10.1016/j.cytogfr.2012.04.001. Epub 2012 May 15. Review.

PMID:
22595692
20.

Interleukin-6 signalling: more than Jaks and STATs.

Eulenfeld R, Dittrich A, Khouri C, Müller PJ, Mütze B, Wolf A, Schaper F.

Eur J Cell Biol. 2012 Jun-Jul;91(6-7):486-95. doi: 10.1016/j.ejcb.2011.09.010. Epub 2011 Dec 3. Review.

PMID:
22138086

Supplemental Content

Loading ...
Support Center