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Items: 1 to 20 of 33

1.

Effects of 3D culturing conditions on the transcriptomic profile of stem-cell-derived neurons.

Tekin H, Simmons S, Cummings B, Gao L, Adiconis X, Hession CC, Ghoshal A, Dionne D, Choudhury SR, Yesilyurt V, Sanjana NE, Shi X, Lu C, Heidenreich M, Pan JQ, Levin JZ, Zhang F.

Nat Biomed Eng. 2018 Jul;2(7):540-554. doi: 10.1038/s41551-018-0219-9. Epub 2018 Apr 9.

2.

A genome-wide net to catch and understand cancer.

Sanjana NE.

Sci Transl Med. 2018 Aug 8;10(453). pii: eaat8288. doi: 10.1126/scitranslmed.aat8288. Review.

PMID:
30089637
3.

GFAP Mutations in Astrocytes Impair Oligodendrocyte Progenitor Proliferation and Myelination in an hiPSC Model of Alexander Disease.

Li L, Tian E, Chen X, Chao J, Klein J, Qu Q, Sun G, Sun G, Huang Y, Warden CD, Ye P, Feng L, Li X, Cui Q, Sultan A, Douvaras P, Fossati V, Sanjana NE, Riggs AD, Shi Y.

Cell Stem Cell. 2018 Aug 2;23(2):239-251.e6. doi: 10.1016/j.stem.2018.07.009.

PMID:
30075130
4.

Two Angelman families with unusually advanced neurodevelopment carry a start codon variant in the most highly expressed UBE3A isoform.

Sadhwani A, Sanjana NE, Willen JM, Calculator SN, Black ED, Bean LJH, Li H, Tan WH.

Am J Med Genet A. 2018 Jul;176(7):1641-1647. doi: 10.1002/ajmg.a.38831. Epub 2018 May 7.

PMID:
29737008
5.

Integrated design, execution, and analysis of arrayed and pooled CRISPR genome-editing experiments.

Canver MC, Haeussler M, Bauer DE, Orkin SH, Sanjana NE, Shalem O, Yuan GC, Zhang F, Concordet JP, Pinello L.

Nat Protoc. 2018 May;13(5):946-986. doi: 10.1038/nprot.2018.005. Epub 2018 Apr 12.

6.

Target Discovery for Precision Medicine Using High-Throughput Genome Engineering.

Guo X, Chitale P, Sanjana NE.

Adv Exp Med Biol. 2017;1016:123-145. doi: 10.1007/978-3-319-63904-8_7. Review.

PMID:
29130157
7.

High-Throughput Approaches to Pinpoint Function within the Noncoding Genome.

Montalbano A, Canver MC, Sanjana NE.

Mol Cell. 2017 Oct 5;68(1):44-59. doi: 10.1016/j.molcel.2017.09.017. Review.

8.

Erratum: Genome-scale activation screen identifies a lncRNA locus regulating a gene neighbourhood.

Joung J, Engreitz JM, Konermann S, Abudayyeh OO, Verdine VK, Aguet F, Gootenberg JS, Sanjana NE, Wright JB, Fulco CP, Tseng YY, Yoon CH, Boehm JS, Lander ES, Zhang F.

Nature. 2017 Sep 20;549(7672):418. doi: 10.1038/nature24009.

PMID:
28933431
9.

GUIDES: sgRNA design for loss-of-function screens.

Meier JA, Zhang F, Sanjana NE.

Nat Methods. 2017 Aug 31;14(9):831-832. doi: 10.1038/nmeth.4423. No abstract available.

10.

Genome-scale activation screen identifies a lncRNA locus regulating a gene neighbourhood.

Joung J, Engreitz JM, Konermann S, Abudayyeh OO, Verdine VK, Aguet F, Gootenberg JS, Sanjana NE, Wright JB, Fulco CP, Tseng YY, Yoon CH, Boehm JS, Lander ES, Zhang F.

Nature. 2017 Aug 17;548(7667):343-346. doi: 10.1038/nature23451. Epub 2017 Aug 11. Erratum in: Nature. 2017 Sep 20;549(7672):418.

11.

Identification of essential genes for cancer immunotherapy.

Patel SJ, Sanjana NE, Kishton RJ, Eidizadeh A, Vodnala SK, Cam M, Gartner JJ, Jia L, Steinberg SM, Yamamoto TN, Merchant AS, Mehta GU, Chichura A, Shalem O, Tran E, Eil R, Sukumar M, Guijarro EP, Day CP, Robbins P, Feldman S, Merlino G, Zhang F, Restifo NP.

Nature. 2017 Aug 31;548(7669):537-542. doi: 10.1038/nature23477. Epub 2017 Aug 7.

12.

Genome-scale CRISPR-Cas9 knockout and transcriptional activation screening.

Joung J, Konermann S, Gootenberg JS, Abudayyeh OO, Platt RJ, Brigham MD, Sanjana NE, Zhang F.

Nat Protoc. 2017 Apr;12(4):828-863. doi: 10.1038/nprot.2017.016. Epub 2017 Mar 23.

13.

Transcription control by the ENL YEATS domain in acute leukaemia.

Erb MA, Scott TG, Li BE, Xie H, Paulk J, Seo HS, Souza A, Roberts JM, Dastjerdi S, Buckley DL, Sanjana NE, Shalem O, Nabet B, Zeid R, Offei-Addo NK, Dhe-Paganon S, Zhang F, Orkin SH, Winter GE, Bradner JE.

Nature. 2017 Mar 9;543(7644):270-274. doi: 10.1038/nature21688. Epub 2017 Mar 1.

14.

Genome-Scale Networks Link Neurodegenerative Disease Genes to ╬▒-Synuclein through Specific Molecular Pathways.

Khurana V, Peng J, Chung CY, Auluck PK, Fanning S, Tardiff DF, Bartels T, Koeva M, Eichhorn SW, Benyamini H, Lou Y, Nutter-Upham A, Baru V, Freyzon Y, Tuncbag N, Costanzo M, San Luis BJ, Sch├Ândorf DC, Barrasa MI, Ehsani S, Sanjana N, Zhong Q, Gasser T, Bartel DP, Vidal M, Deleidi M, Boone C, Fraenkel E, Berger B, Lindquist S.

Cell Syst. 2017 Feb 22;4(2):157-170.e14. doi: 10.1016/j.cels.2016.12.011. Epub 2017 Jan 25.

15.

High-resolution interrogation of functional elements in the noncoding genome.

Sanjana NE, Wright J, Zheng K, Shalem O, Fontanillas P, Joung J, Cheng C, Regev A, Zhang F.

Science. 2016 Sep 30;353(6307):1545-1549.

16.

CRISPR Screens to Discover Functional Noncoding Elements.

Wright JB, Sanjana NE.

Trends Genet. 2016 Sep;32(9):526-529. doi: 10.1016/j.tig.2016.06.004. Epub 2016 Jul 13. Review.

17.

Microfluidic neurite guidance to study structure-function relationships in topologically-complex population-based neural networks.

Honegger T, Thielen MI, Feizi S, Sanjana NE, Voldman J.

Sci Rep. 2016 Jun 22;6:28384. doi: 10.1038/srep28384.

18.

Genome-scale CRISPR pooled screens.

Sanjana NE.

Anal Biochem. 2017 Sep 1;532:95-99. doi: 10.1016/j.ab.2016.05.014. Epub 2016 Jun 1.

19.

GENOME ENGINEERING. The Genome Project-Write.

Boeke JD, Church G, Hessel A, Kelley NJ, Arkin A, Cai Y, Carlson R, Chakravarti A, Cornish VW, Holt L, Isaacs FJ, Kuiken T, Lajoie M, Lessor T, Lunshof J, Maurano MT, Mitchell LA, Rine J, Rosser S, Sanjana NE, Silver PA, Valle D, Wang H, Way JC, Yang L.

Science. 2016 Jul 8;353(6295):126-7. doi: 10.1126/science.aaf6850. Epub 2016 Jun 2. No abstract available.

PMID:
27256881
20.

Hypoxia as a therapy for mitochondrial disease.

Jain IH, Zazzeron L, Goli R, Alexa K, Schatzman-Bone S, Dhillon H, Goldberger O, Peng J, Shalem O, Sanjana NE, Zhang F, Goessling W, Zapol WM, Mootha VK.

Science. 2016 Apr 1;352(6281):54-61. doi: 10.1126/science.aad9642. Epub 2016 Feb 25.

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