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Items: 1 to 20 of 105

1.
2.

Identifying potential novel drugs against Helicobacter pylori by targeting the essential response regulator HsrA.

González A, Salillas S, Velázquez-Campoy A, Espinosa Angarica V, Fillat MF, Sancho J, Lanas Á.

Sci Rep. 2019 Aug 5;9(1):11294. doi: 10.1038/s41598-019-47746-9.

3.

Design, Synthesis, and Efficacy Testing of Nitroethylene- and 7-Nitrobenzoxadiazol-Based Flavodoxin Inhibitors against Helicobacter pylori Drug-Resistant Clinical Strains and in Helicobacter pylori-Infected Mice.

Salillas S, Alías M, Michel V, Mahía A, Lucía A, Rodrigues L, Bueno J, Galano-Frutos JJ, De Reuse H, Velázquez-Campoy A, Carrodeguas JA, Sostres C, Castillo J, Aínsa JA, Díaz-de-Villegas MD, Lanas Á, Touati E, Sancho J.

J Med Chem. 2019 Jul 11;62(13):6102-6115. doi: 10.1021/acs.jmedchem.9b00355. Epub 2019 Jun 21.

PMID:
31244111
4.

Stereoselective synthesis and biological evaluation as inhibitors of hepatitis C virus RNA polymerase of GSK3082 analogues with structural diversity at the 5-position.

Gálvez JA, Clavería-Gimeno R, Galano-Frutos JJ, Sancho J, Velázquez-Campoy A, Abian O, Díaz-de-Villegas MD.

Eur J Med Chem. 2019 Jun 1;171:401-419. doi: 10.1016/j.ejmech.2019.03.019. Epub 2019 Mar 12.

PMID:
30928711
5.

Redox- and Ligand Binding-Dependent Conformational Ensembles in the Human Apoptosis-Inducing Factor Regulate Its Pro-Life and Cell Death Functions.

Villanueva R, Romero-Tamayo S, Laplaza R, Martínez-Olivan J, Velázquez-Campoy A, Sancho J, Ferreira P, Medina M.

Antioxid Redox Signal. 2019 Jun 20;30(18):2013-2029. doi: 10.1089/ars.2018.7658. Epub 2019 Jan 11.

PMID:
30450916
6.

A pyrene-inhibitor fluorescent probe with large Stokes shift for the staining of Aβ1-42, α-synuclein, and amylin amyloid fibrils as well as amyloid-containing Staphylococcus aureus biofilms.

Mahía A, Conde-Giménez M, Salillas S, Pallarés I, Galano-Frutos JJ, Lasa Í, Ventura S, Díaz-de-Villegas MD, Gálvez JA, Sancho J.

Anal Bioanal Chem. 2019 Jan;411(1):251-265. doi: 10.1007/s00216-018-1433-8. Epub 2018 Nov 9.

PMID:
30411148
7.

Identification of Inhibitors Targeting Ferredoxin-NADP⁺ Reductase from the Xanthomonas citri subsp. citri Phytopathogenic Bacteria.

Martínez-Júlvez M, Goñi G, Pérez-Amigot D, Laplaza R, Ionescu IA, Petrocelli S, Tondo ML, Sancho J, Orellano EG, Medina M.

Molecules. 2017 Dec 24;23(1). pii: E29. doi: 10.3390/molecules23010029.

8.

Direct examination of the relevance for folding, binding and electron transfer of a conserved protein folding intermediate.

Lamazares E, Vega S, Ferreira P, Medina M, Galano-Frutos JJ, Martínez-Júlvez M, Velázquez-Campoy A, Sancho J.

Phys Chem Chem Phys. 2017 Jul 26;19(29):19021-19031. doi: 10.1039/c7cp02606d.

PMID:
28702545
9.

High-Throughput Screening Methodology to Identify Alpha-Synuclein Aggregation Inhibitors.

Pujols J, Peña-Díaz S, Conde-Giménez M, Pinheiro F, Navarro S, Sancho J, Ventura S.

Int J Mol Sci. 2017 Mar 2;18(3). pii: E478. doi: 10.3390/ijms18030478.

10.

Streptococcus pneumoniae TIGR4 Flavodoxin: Structural and Biophysical Characterization of a Novel Drug Target.

Rodríguez-Cárdenas Á, Rojas AL, Conde-Giménez M, Velázquez-Campoy A, Hurtado-Guerrero R, Sancho J.

PLoS One. 2016 Sep 20;11(9):e0161020. doi: 10.1371/journal.pone.0161020. eCollection 2016.

11.

Inhibition of Pig Phosphoenolpyruvate Carboxykinase Isoenzymes by 3-Mercaptopicolinic Acid and Novel Inhibitors.

Hidalgo J, Latorre P, Carrodeguas JA, Velázquez-Campoy A, Sancho J, López-Buesa P.

PLoS One. 2016 Jul 8;11(7):e0159002. doi: 10.1371/journal.pone.0159002. eCollection 2016.

12.

Benzbromarone, Quercetin, and Folic Acid Inhibit Amylin Aggregation.

López LC, Varea O, Navarro S, Carrodeguas JA, Sanchez de Groot N, Ventura S, Sancho J.

Int J Mol Sci. 2016 Jun 18;17(6). pii: E964. doi: 10.3390/ijms17060964.

13.

Biophysical Screening for Identifying Pharmacological Chaperones and Inhibitors Against Conformational and Infectious Diseases.

Velazquez-Campoy A, Sancho J, Abian O, Vega S.

Curr Drug Targets. 2016;17(13):1492-505. Review.

PMID:
26844568
14.
16.

The closed conformation of the LDL receptor is destabilized by the low Ca(++) concentration but favored by the high Mg(++) concentration in the endosome.

Martínez-Oliván J, Arias-Moreno X, Hurtado-Guerrero R, Carrodeguas JA, Miguel-Romero L, Marina A, Bruscolini P, Sancho J.

FEBS Lett. 2015 Nov 30;589(23):3534-40. doi: 10.1016/j.febslet.2015.10.014. Epub 2015 Oct 23. Erratum in: FEBS Lett. 2016 Jul;590(14 ):2322.

17.

The mechanism of water/ion exchange at a protein surface: a weakly bound chloride in Helicobacter pylori apoflavodoxin.

Galano-Frutos JJ, Morón MC, Sancho J.

Phys Chem Chem Phys. 2015 Nov 21;17(43):28635-46. doi: 10.1039/c5cp04504e.

PMID:
26443502
18.

In vivo reconstitution of a homodimeric cytochrome b559 like structure: The role of the N-terminus α-subunit from Synechocystis sp. PCC 6803.

Luján MA, Martínez JI, Alonso PJ, Torrado A, Roncel M, Ortega JM, Sancho J, Picorel R.

J Photochem Photobiol B. 2015 Nov;152(Pt B):308-17. doi: 10.1016/j.jphotobiol.2015.07.006. Epub 2015 Jul 8.

19.

Intradomain Confinement of Disulfides in the Folding of Two Consecutive Modules of the LDL Receptor.

Martínez-Oliván J, Fraga H, Arias-Moreno X, Ventura S, Sancho J.

PLoS One. 2015 Jul 13;10(7):e0132141. doi: 10.1371/journal.pone.0132141. eCollection 2015.

20.

Rational stabilization of complex proteins: a divide and combine approach.

Lamazares E, Clemente I, Bueno M, Velázquez-Campoy A, Sancho J.

Sci Rep. 2015 Mar 16;5:9129. doi: 10.1038/srep09129.

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