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J Cutan Pathol. 2008 Dec;35(12):1108-14. doi: 10.1111/j.1600-0560.2008.00986.x. Epub 2008 Jun 18.

Atrophoderma of Pasini and Pierini: a clinical and histopathological study.

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1
Department of Dermatology, American University of Beirut Medical Center, Beirut, Lebanon.

Abstract

BACKGROUND:

Idiopathic atrophoderma of Pasini and Pierini (IAPP) usually manifests as one or multiple depressed and hyperpigmented patches, with a predilection to the trunk. No diagnostic changes are usually seen on histology. Elastic stains often reveal no abnormalities.

OBJECTIVE:

To review our cases of IAPP, describe their clinical and histological findings and compare them with the literature.

METHODS:

Retrospective review of IAPP cases who presented to our institution between 1994 and 2006.

RESULTS:

From a total of 16 patients, only 19% displayed hyperpigmented lesions, while 81% had either hypopigmented (9/16) or skin-colored (4/16) lesions. The sites predominantly affected were the lower extremities (62.5%), followed by the upper extremities and trunk. Only in one patient was IAPP co-existent with morphea. Histology revealed no diagnostic abnormalities; however, elastic stains showed a spectrum of changes ranging from normal to severe diminution and fragmentation of elastic fiber network.

CONCLUSIONS:

Our study shows several new aspects of IAPP. Clinically, the lesions were most commonly hypopigmented and involved predominantly the extremities. Histologically, IAPP exhibited a spectrum of alterations in elastic fibers. The most prevalent form of IAPP in our country seems to be unassociated with morphea.

[Indexed for MEDLINE]

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