Format

Send to

Choose Destination
Blood Adv. 2017 Jul 31;1(18):1382-1386. doi: 10.1182/bloodadvances.2016002725. eCollection 2017 Aug 8.

Overexpression of RUNX1 short isoform has an important role in the development of myelodysplastic/myeloproliferative neoplasms.

Author information

1
Department of Hematology, Juntendo University School of Medicine, Tokyo, Japan.
2
Department of Clinical Laboratory Medicine, Bunkyo Gakuin University, Tokyo, Japan.
3
Laboratory of Oncology, School of Life Sciences, Tokyo University of Pharmacy and Life Sciences, Hachioji, Japan.
4
Tokyo Metropolitan Cancer and Infectious Disease Center Komagome Hospital, Tokyo, Japan; and.
5
Division of Cellular Therapy, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan.

Abstract

RUNX1a, but not RUNX1b, is overexpressed in CD34+ cells from patients with myelodysplastic/myeloproliferative neoplasms.SRSF2P95H mutation induces RUNX1a overexpression and a monocytic phenotype in TF-1 cells.

Conflict of interest statement

Conflict-of-interest disclosure: The authors declare no competing financial interests.

Supplemental Content

Full text links

Icon for HighWire Icon for PubMed Central
Loading ...
Support Center