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Blood Adv. 2017 Jul 31;1(18):1382-1386. doi: 10.1182/bloodadvances.2016002725. eCollection 2017 Aug 8.

Overexpression of RUNX1 short isoform has an important role in the development of myelodysplastic/myeloproliferative neoplasms.

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Department of Hematology, Juntendo University School of Medicine, Tokyo, Japan.
Department of Clinical Laboratory Medicine, Bunkyo Gakuin University, Tokyo, Japan.
Laboratory of Oncology, School of Life Sciences, Tokyo University of Pharmacy and Life Sciences, Hachioji, Japan.
Tokyo Metropolitan Cancer and Infectious Disease Center Komagome Hospital, Tokyo, Japan; and.
Division of Cellular Therapy, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan.


RUNX1a, but not RUNX1b, is overexpressed in CD34+ cells from patients with myelodysplastic/myeloproliferative neoplasms.SRSF2P95H mutation induces RUNX1a overexpression and a monocytic phenotype in TF-1 cells.

Conflict of interest statement

Conflict-of-interest disclosure: The authors declare no competing financial interests.

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