SMYD2 regulates vascular smooth muscle cell phenotypic switching and intimal hyperplasia via interaction with myocardin.
Zhou Y, Sharma S, Sun X, Guan X, Hou Y, Yang Z, Shi H, Zou MH, Song P, Zhou J, Wang S, Hu Z, Li C.
Zhou Y, et al.
Cell Mol Life Sci. 2023 Aug 24;80(9):264. doi: 10.1007/s00018-023-04883-9.
Cell Mol Life Sci. 2023.
PMID: 37615725
Using an SMC-specific SMYD2 knockout mouse model, we found that SMYD2 ablation in VSMCs exacerbated neointima formation after vascular injury in vivo. ...In addition, myocardin directly interacted with SMYD2, thereby facilitating SMYD2 recruitment to t …
Using an SMC-specific SMYD2 knockout mouse model, we found that SMYD2 ablation in VSMCs exacerbated neointima formation after …