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Role of SLC5A8, a plasma membrane transporter and a tumor suppressor, in the antitumor activity of dichloroacetate.
Babu E, Ramachandran S, CoothanKandaswamy V, Elangovan S, Prasad PD, Ganapathy V, Thangaraju M. Babu E, et al. Oncogene. 2011 Sep 22;30(38):4026-37. doi: 10.1038/onc.2011.113. Epub 2011 Apr 18. Oncogene. 2011. PMID: 21499304 Free PMC article.
We hypothesized that lack of effective mechanisms for the entry of DCA into tumor cells may underlie this phenomenon. Here we show that SLC5A8 transports DCA very effectively with high affinity. ...The mechanism of the compound's antitumor activity still rema …
We hypothesized that lack of effective mechanisms for the entry of DCA into tumor cells may underlie this phenomenon. Here we show th …
The Comparative Experimental Study of Sodium and Magnesium Dichloroacetate Effects on Pediatric PBT24 and SF8628 Cell Glioblastoma Tumors Using a Chicken Embryo Chorioallantoic Membrane Model and on Cells In Vitro.
Damanskienė E, Balnytė I, Valančiūtė A, Lesauskaitė V, Alonso MM, Stakišaitis D. Damanskienė E, et al. Int J Mol Sci. 2022 Sep 9;23(18):10455. doi: 10.3390/ijms231810455. Int J Mol Sci. 2022. PMID: 36142368 Free PMC article.
The cells were also treated with 3 mM DCA. Both the 10 mM DCA preparations significantly reduced PBT24 and SF8624 tumor invasion rates, while 5 mM NaDCA reduced it only in the SF8628 tumors. ...The DCA treatment did not affect the SLC12A2, SLC12A5, and SLC …
The cells were also treated with 3 mM DCA. Both the 10 mM DCA preparations significantly reduced PBT24 and SF8624 tumor invasi …
Preclinical Study in Mouse Thymus and Thymocytes: Effects of Treatment with a Combination of Sodium Dichloroacetate and Sodium Valproate on Infectious Inflammation Pathways.
Stakišaitis D, Kapočius L, Kilimaitė E, Gečys D, Šlekienė L, Balnytė I, Palubinskienė J, Lesauskaitė V. Stakišaitis D, et al. Pharmaceutics. 2023 Nov 30;15(12):2715. doi: 10.3390/pharmaceutics15122715. Pharmaceutics. 2023. PMID: 38140056 Free PMC article.
The research presents data from a preclinical study on the anti-inflammatory effects of a sodium dichloroacetate and sodium valproate combination (DCA-VPA). The 2-week treatment with a DCA 100 mg/kg/day and VPA 150 mg/kg/day combination solution in drinking water's …
The research presents data from a preclinical study on the anti-inflammatory effects of a sodium dichloroacetate and sodium valproate combin …