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Eur J Pharmacol. 2006 Feb 15;531(1-3):254-8. Epub 2006 Jan 24.

S-nitrosocysteine elicits hemodynamic responses similar to those of the Bezold-Jarisch reflex via activation of stereoselective recognition sites.

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Department of Pharmacology and Physiology, University of Georgia, Athens, Georgia 30602-7389, USA.


We report here that L-S-nitrosocysteine elicits rapid dose-dependent reductions in mean arterial blood pressure, heart rate, cardiac output and renal sympathetic nerve activity in conscious rats whereas D-S-nitrosocysteine elicits minor responses. The reductions in mean arterial blood pressure, heart rate and cardiac output elicited by L- and D-S-nitrosocysteine were markedly diminished after blockade of cardiac muscarinic cholinergic receptors whereas the reductions in renal sympathetic nerve activity were not affected. The Bezold-Jarisch reflex-like pattern of responses elicited by the stereoisomers, suggests that (i) L- and L-S-nitrosocysteine may activate stereoselective recognition sites on vagal cardiopulmonary afferents, which elicit hemodynamic responses via increases in cardiovagal efferent nerve activity and decreases in sympathetic nerve activity, and (ii) L-S-nitrosocysteine is a more potent agonist of these recognition sites than is D-S-nitrosocysteine.

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