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Items: 1 to 20 of 116

1.

Material microenvironmental properties couple to induce distinct transcriptional programs in mammalian stem cells.

Darnell M, O'Neil A, Mao A, Gu L, Rubin LL, Mooney DJ.

Proc Natl Acad Sci U S A. 2018 Sep 4;115(36):E8368-E8377. doi: 10.1073/pnas.1802568115. Epub 2018 Aug 17.

PMID:
30120125
2.

Using Automated Live Cell Imaging to Reveal Early Changes during Human Motor Neuron Degeneration.

Shin HY, Pfaff KL, Davidow LS, Sun C, Uozumi T, Yanagawa F, Yamazaki Y, Kiyota Y, Rubin LL.

eNeuro. 2018 Jun 29;5(3). pii: ENEURO.0001-18.2018. doi: 10.1523/ENEURO.0001-18.2018. eCollection 2018 May-Jun.

3.

Toward Precision Medicine for Neurological and Neuropsychiatric Disorders.

Gibbs RM, Lipnick S, Bateman JW, Chen L, Cousins HC, Hubbard EG, Jowett G, LaPointe DS, McGredy MJ, Odonkor MN, Repetti G, Thomas E, Rubin LL.

Cell Stem Cell. 2018 Jul 5;23(1):21-24. doi: 10.1016/j.stem.2018.05.019. Epub 2018 Jun 7.

PMID:
29887317
4.

Blocking p62-dependent SMN degradation ameliorates spinal muscular atrophy disease phenotypes.

Rodriguez-Muela N, Parkhitko A, Grass T, Gibbs RM, Norabuena EM, Perrimon N, Singh R, Rubin LL.

J Clin Invest. 2018 Jul 2;128(7):3008-3023. doi: 10.1172/JCI95231. Epub 2018 Jun 11.

5.

Dynamics of PARKIN-Dependent Mitochondrial Ubiquitylation in Induced Neurons and Model Systems Revealed by Digital Snapshot Proteomics.

Ordureau A, Paulo JA, Zhang W, Ahfeldt T, Zhang J, Cohn EF, Hou Z, Heo JM, Rubin LL, Sidhu SS, Gygi SP, Harper JW.

Mol Cell. 2018 Apr 19;70(2):211-227.e8. doi: 10.1016/j.molcel.2018.03.012. Epub 2018 Apr 12.

PMID:
29656925
6.

In Silico Labeling: Predicting Fluorescent Labels in Unlabeled Images.

Christiansen EM, Yang SJ, Ando DM, Javaherian A, Skibinski G, Lipnick S, Mount E, O'Neil A, Shah K, Lee AK, Goyal P, Fedus W, Poplin R, Esteva A, Berndl M, Rubin LL, Nelson P, Finkbeiner S.

Cell. 2018 Apr 19;173(3):792-803.e19. doi: 10.1016/j.cell.2018.03.040. Epub 2018 Apr 12.

PMID:
29656897
7.

Using intracellular markers to identify a novel set of surface markers for live cell purification from a heterogeneous hIPSC culture.

Paik EJ, O'Neil AL, Ng SY, Sun C, Rubin LL.

Sci Rep. 2018 Jan 16;8(1):804. doi: 10.1038/s41598-018-19291-4.

8.

A neuroprotective agent that inactivates prodegenerative TrkA and preserves mitochondria.

Feinberg K, Kolaj A, Wu C, Grinshtein N, Krieger JR, Moran MF, Rubin LL, Miller FD, Kaplan DR.

J Cell Biol. 2017 Nov 6;216(11):3655-3675. doi: 10.1083/jcb.201705085. Epub 2017 Sep 6.

9.

Reactive Astrocytes Promote ALS-like Degeneration and Intracellular Protein Aggregation in Human Motor Neurons by Disrupting Autophagy through TGF-β1.

Tripathi P, Rodriguez-Muela N, Klim JR, de Boer AS, Agrawal S, Sandoe J, Lopes CS, Ogliari KS, Williams LA, Shear M, Rubin LL, Eggan K, Zhou Q.

Stem Cell Reports. 2017 Aug 8;9(2):667-680. doi: 10.1016/j.stemcr.2017.06.008. Epub 2017 Jul 14.

10.

Subtly Modulating Glycogen Synthase Kinase 3 β: Allosteric Inhibitor Development and Their Potential for the Treatment of Chronic Diseases.

Palomo V, Perez DI, Roca C, Anderson C, Rodríguez-Muela N, Perez C, Morales-Garcia JA, Reyes JA, Campillo NE, Perez-Castillo AM, Rubin LL, Timchenko L, Gil C, Martinez A.

J Med Chem. 2017 Jun 22;60(12):4983-5001. doi: 10.1021/acs.jmedchem.7b00395. Epub 2017 Jun 6.

PMID:
28548834
11.

Single-Cell Analysis of SMN Reveals Its Broader Role in Neuromuscular Disease.

Rodriguez-Muela N, Litterman NK, Norabuena EM, Mull JL, Galazo MJ, Sun C, Ng SY, Makhortova NR, White A, Lynes MM, Chung WK, Davidow LS, Macklis JD, Rubin LL.

Cell Rep. 2017 Feb 7;18(6):1484-1498. doi: 10.1016/j.celrep.2017.01.035.

12.

The Antisense Transcript SMN-AS1 Regulates SMN Expression and Is a Novel Therapeutic Target for Spinal Muscular Atrophy.

d'Ydewalle C, Ramos DM, Pyles NJ, Ng SY, Gorz M, Pilato CM, Ling K, Kong L, Ward AJ, Rubin LL, Rigo F, Bennett CF, Sumner CJ.

Neuron. 2017 Jan 4;93(1):66-79. doi: 10.1016/j.neuron.2016.11.033. Epub 2016 Dec 22.

13.

Large-Scale Production of Mature Neurons from Human Pluripotent Stem Cells in a Three-Dimensional Suspension Culture System.

Rigamonti A, Repetti GG, Sun C, Price FD, Reny DC, Rapino F, Weisinger K, Benkler C, Peterson QP, Davidow LS, Hansson EM, Rubin LL.

Stem Cell Reports. 2016 Jun 14;6(6):993-1008. doi: 10.1016/j.stemcr.2016.05.010.

14.

Studying human disease using human neurons.

Ahfeldt T, Litterman NK, Rubin LL.

Brain Res. 2017 Feb 1;1656:40-48. doi: 10.1016/j.brainres.2016.03.051. Epub 2016 Apr 6. Review.

15.

Biochemistry and Biology of GDF11 and Myostatin: Similarities, Differences, and Questions for Future Investigation.

Walker RG, Poggioli T, Katsimpardi L, Buchanan SM, Oh J, Wattrus S, Heidecker B, Fong YW, Rubin LL, Ganz P, Thompson TB, Wagers AJ, Lee RT.

Circ Res. 2016 Apr 1;118(7):1125-41; discussion 1142. doi: 10.1161/CIRCRESAHA.116.308391. Review.

16.

Creating Patient-Specific Neural Cells for the In Vitro Study of Brain Disorders.

Brennand KJ, Marchetto MC, Benvenisty N, Brüstle O, Ebert A, Izpisua Belmonte JC, Kaykas A, Lancaster MA, Livesey FJ, McConnell MJ, McKay RD, Morrow EM, Muotri AR, Panchision DM, Rubin LL, Sawa A, Soldner F, Song H, Studer L, Temple S, Vaccarino FM, Wu J, Vanderhaeghen P, Gage FH, Jaenisch R.

Stem Cell Reports. 2015 Dec 8;5(6):933-945. doi: 10.1016/j.stemcr.2015.10.011. Epub 2015 Nov 21.

17.

Genome-wide RNA-Seq of Human Motor Neurons Implicates Selective ER Stress Activation in Spinal Muscular Atrophy.

Ng SY, Soh BS, Rodriguez-Muela N, Hendrickson DG, Price F, Rinn JL, Rubin LL.

Cell Stem Cell. 2015 Nov 5;17(5):569-84. doi: 10.1016/j.stem.2015.08.003. Epub 2015 Aug 27.

18.

Clonal analyses and gene profiling identify genetic biomarkers of the thermogenic potential of human brown and white preadipocytes.

Xue R, Lynes MD, Dreyfuss JM, Shamsi F, Schulz TJ, Zhang H, Huang TL, Townsend KL, Li Y, Takahashi H, Weiner LS, White AP, Lynes MS, Rubin LL, Goodyear LJ, Cypess AM, Tseng YH.

Nat Med. 2015 Jul;21(7):760-8. doi: 10.1038/nm.3881. Epub 2015 Jun 15.

19.

Young systemic factors as a medicine for age-related neurodegenerative diseases.

Katsimpardi L, Rubin LL.

Neurogenesis (Austin). 2015 Feb 3;2(1):e1004971. doi: 10.1080/23262133.2015.1004971. eCollection 2015.

20.

A comparison of non-integrating reprogramming methods.

Schlaeger TM, Daheron L, Brickler TR, Entwisle S, Chan K, Cianci A, DeVine A, Ettenger A, Fitzgerald K, Godfrey M, Gupta D, McPherson J, Malwadkar P, Gupta M, Bell B, Doi A, Jung N, Li X, Lynes MS, Brookes E, Cherry AB, Demirbas D, Tsankov AM, Zon LI, Rubin LL, Feinberg AP, Meissner A, Cowan CA, Daley GQ.

Nat Biotechnol. 2015 Jan;33(1):58-63. doi: 10.1038/nbt.3070. Epub 2014 Dec 1.

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