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Items: 1 to 20 of 55


Treating the "Wake-up Call" of Alcohol Use: A Teachable Moment.

Roy PJ, Worsham C.

JAMA Intern Med. 2017 Dec 1;177(12):1849-1850. doi: 10.1001/jamainternmed.2017.5502. No abstract available.


The novel nematicide wact-86 interacts with aldicarb to kill nematodes.

Burns AR, Bagg R, Yeo M, Luciani GM, Schertzberg M, Fraser AG, Roy PJ.

PLoS Negl Trop Dis. 2017 Apr 5;11(4):e0005502. doi: 10.1371/journal.pntd.0005502. eCollection 2017 Apr.


The MADD-3 LAMMER Kinase Interacts with a p38 MAP Kinase Pathway to Regulate the Display of the EVA-1 Guidance Receptor in Caenorhabditis elegans.

D'Souza SA, Rajendran L, Bagg R, Barbier L, van Pel DM, Moshiri H, Roy PJ.

PLoS Genet. 2016 Apr 28;12(4):e1006010. doi: 10.1371/journal.pgen.1006010. eCollection 2016 Apr.


Caenorhabditis elegans is a useful model for anthelmintic discovery.

Burns AR, Luciani GM, Musso G, Bagg R, Yeo M, Zhang Y, Rajendran L, Glavin J, Hunter R, Redman E, Stasiuk S, Schertzberg M, Angus McQuibban G, Caffrey CR, Cutler SR, Tyers M, Giaever G, Nislow C, Fraser AG, MacRae CA, Gilleard J, Roy PJ.

Nat Commun. 2015 Jun 25;6:7485. doi: 10.1038/ncomms8485.


EVA-1 functions as an UNC-40 Co-receptor to enhance attraction to the MADD-4 guidance cue in Caenorhabditis elegans.

Chan KK, Seetharaman A, Bagg R, Selman G, Zhang Y, Kim J, Roy PJ.

PLoS Genet. 2014 Aug 14;10(8):e1004521. doi: 10.1371/journal.pgen.1004521. eCollection 2014 Aug.


Orthosteric and allosteric drug binding sites in the Caenorhabditis elegans mgl-2 metabotropic glutamate receptor.

Tharmalingam S, Burns AR, Roy PJ, Hampson DR.

Neuropharmacology. 2012 Sep;63(4):667-74. doi: 10.1016/j.neuropharm.2012.05.029. Epub 2012 May 28.


Dafadine inhibits DAF-9 to promote dauer formation and longevity of Caenorhabditis elegans.

Luciani GM, Magomedova L, Puckrin R, Urbanus ML, Wallace IM, Giaever G, Nislow C, Cummins CL, Roy PJ.

Nat Chem Biol. 2011 Nov 6;7(12):891-3. doi: 10.1038/nchembio.698. Erratum in: Nat Chem Biol. 2012 Mar;8(3):318.


Compound prioritization methods increase rates of chemical probe discovery in model organisms.

Wallace IM, Urbanus ML, Luciani GM, Burns AR, Han MK, Wang H, Arora K, Heisler LE, Proctor M, St Onge RP, Roemer T, Roy PJ, Cummins CL, Bader GD, Nislow C, Giaever G.

Chem Biol. 2011 Oct 28;18(10):1273-83. doi: 10.1016/j.chembiol.2011.07.018.


MADD-4 is a secreted cue required for midline-oriented guidance in Caenorhabditis elegans.

Seetharaman A, Selman G, Puckrin R, Barbier L, Wong E, D'Souza SA, Roy PJ.

Dev Cell. 2011 Oct 18;21(4):669-80. doi: 10.1016/j.devcel.2011.07.020.


MADD-2, a homolog of the Opitz syndrome protein MID1, regulates guidance to the midline through UNC-40 in Caenorhabditis elegans.

Alexander M, Selman G, Seetharaman A, Chan KK, D'Souza SA, Byrne AB, Roy PJ.

Dev Cell. 2010 Jun 15;18(6):961-72. doi: 10.1016/j.devcel.2010.05.016.


A predictive model for drug bioaccumulation and bioactivity in Caenorhabditis elegans.

Burns AR, Wallace IM, Wildenhain J, Tyers M, Giaever G, Bader GD, Nislow C, Cutler SR, Roy PJ.

Nat Chem Biol. 2010 Jul;6(7):549-57. doi: 10.1038/nchembio.380. Epub 2010 May 30.


Seeing through the smokescreen.

Roy PJ.

Med Econ. 2010 Mar 5;87(5):55. No abstract available.


An UNC-40 pathway directs postsynaptic membrane extension in Caenorhabditis elegans.

Alexander M, Chan KK, Byrne AB, Selman G, Lee T, Ono J, Wong E, Puckrin R, Dixon SJ, Roy PJ.

Development. 2009 Mar;136(6):911-22. doi: 10.1242/dev.030759. Epub 2009 Feb 11.


Differential sensitivities of CaV1.2 IIS5-S6 mutants to 1,4-dihydropyridine analogs.

Hui K, Kwok TC, Kostelecki W, Leen J, Roy PJ, Feng ZP.

Eur J Pharmacol. 2009 Jan 14;602(2-3):255-61. doi: 10.1016/j.ejphar.2008.11.051. Epub 2008 Dec 3.


A genetic screen for dihydropyridine (DHP)-resistant worms reveals new residues required for DHP-blockage of mammalian calcium channels.

Kwok TC, Hui K, Kostelecki W, Ricker N, Selman G, Feng ZP, Roy PJ.

PLoS Genet. 2008 May 9;4(5):e1000067. doi: 10.1371/journal.pgen.1000067. Erratum in: PLoS Genet. 2009 Feb;5(2). doi: 10.1371/annotation/c38f7645-c9d8-4371-b363-5a9099c75e83.


Identification of small molecule inhibitors of Pseudomonas aeruginosa exoenzyme S using a yeast phenotypic screen.

Arnoldo A, Curak J, Kittanakom S, Chevelev I, Lee VT, Sahebol-Amri M, Koscik B, Ljuma L, Roy PJ, Bedalov A, Giaever G, Nislow C, Merrill AR, Lory S, Stagljar I.

PLoS Genet. 2008 Feb 29;4(2):e1000005. doi: 10.1371/journal.pgen.1000005. Erratum in: PLoS Genet. 2008 Apr;4(4). doi: 10.1371/annotation/76d35829-07a2-479f-bbc1-cce6755b6d8c. Merrill, Rod A [corrected to Merrill, A Rod].


Insulin-like signaling negatively regulates muscle arm extension through DAF-12 in Caenorhabditis elegans.

Dixon SJ, Alexander M, Chan KK, Roy PJ.

Dev Biol. 2008 Jun 1;318(1):153-61. doi: 10.1016/j.ydbio.2008.03.019. Epub 2008 Mar 20.


Worming our way to the fountain of youth.

Roy PJ.

Nat Chem Biol. 2008 Feb;4(2):88-9. doi: 10.1038/nchembio0208-88. No abstract available.


Health plan ignorance can cost you.

Roy PJ.

Med Econ. 2007 Nov 2;84(21):48-9. No abstract available.


A global analysis of genetic interactions in Caenorhabditis elegans.

Byrne AB, Weirauch MT, Wong V, Koeva M, Dixon SJ, Stuart JM, Roy PJ.

J Biol. 2007;6(3):8. Epub 2007 Sep 26.

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