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Chem Commun (Camb). 2011 Aug 14;47(30):8524-6. doi: 10.1039/c1cc12805a. Epub 2011 Jun 30.

Kinetic discrimination in recognition of DNA quadruplex targets by guanine-rich heteroquadruplex-forming PNA probes.

Author information

1
Department of Chemistry and Center for Nucleic Acids Science and Technology, Carnegie Mellon University, 4400 Fifth Avenue, Pittsburgh, PA 15213, USA.

Abstract

Guanine-rich peptide nucleic acid probes hybridize to DNA G quadruplex targets with high affinity, forming PNA-DNA heteroquadruplexes. We report a surprising degree of kinetic discrimination for PNA heteroquadruplex formation with a series of DNA targets. The fastest hybridization is observed for targets folded into parallel morphologies.

PMID:
21717030
PMCID:
PMC3163151
DOI:
10.1039/c1cc12805a
[Indexed for MEDLINE]
Free PMC Article

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