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Items: 1 to 20 of 46

1.

Selective binding of the PHD6 finger of MLL4 to histone H4K16ac links MLL4 and MOF.

Zhang Y, Jang Y, Lee JE, Ahn J, Xu L, Holden MR, Cornett EM, Krajewski K, Klein BJ, Wang SP, Dou Y, Roeder RG, Strahl BD, Rothbart SB, Shi X, Ge K, Kutateladze TG.

Nat Commun. 2019 May 24;10(1):2314. doi: 10.1038/s41467-019-10324-8.

2.

Defining UHRF1 Domains that Support Maintenance of Human Colon Cancer DNA Methylation and Oncogenic Properties.

Kong X, Chen J, Xie W, Brown SM, Cai Y, Wu K, Fan D, Nie Y, Yegnasubramanian S, Tiedemann RL, Tao Y, Chiu Yen RW, Topper MJ, Zahnow CA, Easwaran H, Rothbart SB, Xia L, Baylin SB.

Cancer Cell. 2019 Apr 15;35(4):633-648.e7. doi: 10.1016/j.ccell.2019.03.003. Epub 2019 Apr 4.

PMID:
30956060
3.

Trabectedin Inhibits EWS-FLI1 and Evicts SWI/SNF from Chromatin in a Schedule-dependent Manner.

Harlow ML, Chasse MH, Boguslawski EA, Sorensen KM, Gedminas JM, Kitchen-Goosen SM, Rothbart SB, Taslim C, Lessnick SL, Peck AS, Madaj ZB, Bowman MJ, Grohar PJ.

Clin Cancer Res. 2019 Jun 1;25(11):3417-3429. doi: 10.1158/1078-0432.CCR-18-3511. Epub 2019 Feb 5.

PMID:
30723142
4.

A DNA methylation reader complex that enhances gene transcription.

Harris CJ, Scheibe M, Wongpalee SP, Liu W, Cornett EM, Vaughan RM, Li X, Chen W, Xue Y, Zhong Z, Yen L, Barshop WD, Rayatpisheh S, Gallego-Bartolome J, Groth M, Wang Z, Wohlschlegel JA, Du J, Rothbart SB, Butter F, Jacobsen SE.

Science. 2018 Dec 7;362(6419):1182-1186. doi: 10.1126/science.aar7854.

PMID:
30523112
5.

A functional proteomics platform to reveal the sequence determinants of lysine methyltransferase substrate selectivity.

Cornett EM, Dickson BM, Krajewski K, Spellmon N, Umstead A, Vaughan RM, Shaw KM, Versluis PP, Cowles MW, Brunzelle J, Yang Z, Vega IE, Sun ZW, Rothbart SB.

Sci Adv. 2018 Nov 28;4(11):eaav2623. doi: 10.1126/sciadv.aav2623. eCollection 2018 Nov.

6.

Examining the Roles of H3K4 Methylation States with Systematically Characterized Antibodies.

Shah RN, Grzybowski AT, Cornett EM, Johnstone AL, Dickson BM, Boone BA, Cheek MA, Cowles MW, Maryanski D, Meiners MJ, Tiedemann RL, Vaughan RM, Arora N, Sun ZW, Rothbart SB, Keogh MC, Ruthenburg AJ.

Mol Cell. 2018 Oct 4;72(1):162-177.e7. doi: 10.1016/j.molcel.2018.08.015. Epub 2018 Sep 20.

PMID:
30244833
7.

Study of mitotic chromatin supports a model of bookmarking by histone modifications and reveals nucleosome deposition patterns.

Javasky E, Shamir I, Gandhi S, Egri S, Sandler O, Rothbart SB, Kaplan N, Jaffe JD, Goren A, Simon I.

Genome Res. 2018 Oct;28(10):1455-1466. doi: 10.1101/gr.230300.117. Epub 2018 Aug 30.

8.

Chromatin structure and its chemical modifications regulate the ubiquitin ligase substrate selectivity of UHRF1.

Vaughan RM, Dickson BM, Whelihan MF, Johnstone AL, Cornett EM, Cheek MA, Ausherman CA, Cowles MW, Sun ZW, Rothbart SB.

Proc Natl Acad Sci U S A. 2018 Aug 28;115(35):8775-8780. doi: 10.1073/pnas.1806373115. Epub 2018 Aug 13.

9.

Comparative biochemical analysis of UHRF proteins reveals molecular mechanisms that uncouple UHRF2 from DNA methylation maintenance.

Vaughan RM, Dickson BM, Cornett EM, Harrison JS, Kuhlman B, Rothbart SB.

Nucleic Acids Res. 2018 May 18;46(9):4405-4416. doi: 10.1093/nar/gky151.

10.

Structural basis for DNMT3A-mediated de novo DNA methylation.

Zhang ZM, Lu R, Wang P, Yu Y, Chen D, Gao L, Liu S, Ji D, Rothbart SB, Wang Y, Wang GG, Song J.

Nature. 2018 Feb 15;554(7692):387-391. doi: 10.1038/nature25477. Epub 2018 Feb 7.

11.

The Arginine Methyltransferase PRMT6 Regulates DNA Methylation and Contributes to Global DNA Hypomethylation in Cancer.

Veland N, Hardikar S, Zhong Y, Gayatri S, Dan J, Strahl BD, Rothbart SB, Bedford MT, Chen T.

Cell Rep. 2017 Dec 19;21(12):3390-3397. doi: 10.1016/j.celrep.2017.11.082.

12.

Analysis of Histone Antibody Specificity with Peptide Microarrays.

Cornett EM, Dickson BM, Rothbart SB.

J Vis Exp. 2017 Aug 1;(126). doi: 10.3791/55912.

13.

A D53 repression motif induces oligomerization of TOPLESS corepressors and promotes assembly of a corepressor-nucleosome complex.

Ma H, Duan J, Ke J, He Y, Gu X, Xu TH, Yu H, Wang Y, Brunzelle JS, Jiang Y, Rothbart SB, Xu HE, Li J, Melcher K.

Sci Adv. 2017 Jun 2;3(6):e1601217. doi: 10.1126/sciadv.1601217. eCollection 2017 Jun.

14.

Histone peptide microarray screen of chromo and Tudor domains defines new histone lysine methylation interactions.

Shanle EK, Shinsky SA, Bridgers JB, Bae N, Sagum C, Krajewski K, Rothbart SB, Bedford MT, Strahl BD.

Epigenetics Chromatin. 2017 Mar 14;10:12. doi: 10.1186/s13072-017-0117-5. eCollection 2017.

15.

Systematic comparison of monoclonal versus polyclonal antibodies for mapping histone modifications by ChIP-seq.

Busby M, Xue C, Li C, Farjoun Y, Gienger E, Yofe I, Gladden A, Epstein CB, Cornett EM, Rothbart SB, Nusbaum C, Goren A.

Epigenetics Chromatin. 2016 Nov 4;9:49. eCollection 2016.

16.

A fast, open source implementation of adaptive biasing potentials uncovers a ligand design strategy for the chromatin regulator BRD4.

Dickson BM, de Waal PW, Ramjan ZH, Xu HE, Rothbart SB.

J Chem Phys. 2016 Oct 21;145(15):154113.

17.

Multivalent Chromatin Engagement and Inter-domain Crosstalk Regulate MORC3 ATPase.

Andrews FH, Tong Q, Sullivan KD, Cornett EM, Zhang Y, Ali M, Ahn J, Pandey A, Guo AH, Strahl BD, Costello JC, Espinosa JM, Rothbart SB, Kutateladze TG.

Cell Rep. 2016 Sep 20;16(12):3195-3207. doi: 10.1016/j.celrep.2016.08.050.

18.

Hemi-methylated DNA regulates DNA methylation inheritance through allosteric activation of H3 ubiquitylation by UHRF1.

Harrison JS, Cornett EM, Goldfarb D, DaRosa PA, Li ZM, Yan F, Dickson BM, Guo AH, Cantu DV, Kaustov L, Brown PJ, Arrowsmith CH, Erie DA, Major MB, Klevit RE, Krajewski K, Kuhlman B, Strahl BD, Rothbart SB.

Elife. 2016 Sep 6;5. pii: e17101. doi: 10.7554/eLife.17101.

19.

ArrayNinja: An Open Source Platform for Unified Planning and Analysis of Microarray Experiments.

Dickson BM, Cornett EM, Ramjan Z, Rothbart SB.

Methods Enzymol. 2016;574:53-77. doi: 10.1016/bs.mie.2016.02.002. Epub 2016 Mar 2.

20.

Substrate Specificity Profiling of Histone-Modifying Enzymes by Peptide Microarray.

Cornett EM, Dickson BM, Vaughan RM, Krishnan S, Trievel RC, Strahl BD, Rothbart SB.

Methods Enzymol. 2016;574:31-52. doi: 10.1016/bs.mie.2016.01.008. Epub 2016 Feb 16.

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