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The inhibitory Fc gamma IIb receptor dampens TLR4-mediated immune responses and is selectively up-regulated on dendritic cells from rheumatoid arthritis patients with quiescent disease.
Wenink MH, Santegoets KC, Roelofs MF, Huijbens R, Koenen HJ, van Beek R, Joosten I, Meyer-Wentrup F, Mathsson L, Ronnelid J, Adema GJ, Bonvini E, Koenig S, van den Berg WB, van Riel PL, Radstake TR. Wenink MH, et al. Among authors: roelofs mf. J Immunol. 2009 Oct 1;183(7):4509-20. doi: 10.4049/jimmunol.0900153. Epub 2009 Sep 4. J Immunol. 2009. PMID: 19734236
The expression of toll-like receptors 3 and 7 in rheumatoid arthritis synovium is increased and costimulation of toll-like receptors 3, 4, and 7/8 results in synergistic cytokine production by dendritic cells.
Roelofs MF, Joosten LA, Abdollahi-Roodsaz S, van Lieshout AW, Sprong T, van den Hoogen FH, van den Berg WB, Radstake TR. Roelofs MF, et al. Arthritis Rheum. 2005 Aug;52(8):2313-22. doi: 10.1002/art.21278. Arthritis Rheum. 2005. PMID: 16052591 Free article.
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