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Int J Mol Sci. 2018 Apr 10;19(4). pii: E1137. doi: 10.3390/ijms19041137.

Rhodobacter sphaeroides Extract Lycogen™ Attenuates Testosterone-Induced Benign Prostate Hyperplasia in Rats.

Wang CT1,2, Wang YY3,4, Liu WS5,6, Cheng CM7, Chiu KH8, Liu LL9, Liu XZ10, Wen ZH11, Chen YH12,13,14, Chen TM15.

Author information

1
Department of Marine Biotechnology and Resources, National Sun Yat-sen University, 70 Lienhai Rd., Kaohsiung 80424, Taiwan. wct5816@gmail.com.
2
Department of Medicine, Kaohsiung Armed Forces General Hospital, Kaohsiung 80284, Taiwan. wct5816@gmail.com.
3
Department of Chemistry, Fu Jen Catholic University, New Taipei City 24205, Taiwan. vic0009@gmail.com.
4
Graduate Institute of Biomedical and Pharmaceutical Science, Fu Jen Catholic University, New Taipei City 24205, Taiwan. vic0009@gmail.com.
5
Asia-Pacific Biotech Developing, Inc., Kaohsiung 80681, Taiwan. wensheng5394@gmail.com.
6
Department and Graduate Institute of Aquaculture, National Kaohsiung University of Science and Technology, No.142, Haijhuan Rd., Nazih Dist., Kaohsiung 81157, Taiwan. wensheng5394@gmail.com.
7
Department of Animal Pharmacology, Development Centre for Biotechnology, New Taipei City 22180, Taiwan. chunming@dcb.org.tw.
8
Department and Graduate Institute of Aquaculture, National Kaohsiung University of Science and Technology, No.142, Haijhuan Rd., Nazih Dist., Kaohsiung 81157, Taiwan. kuohsun@webmail.nkmu.edu.tw.
9
Department of Oceanography, National Sun Yat-sen University, Kaohsiung 80424, Taiwan. lilian@mail.nsysu.edu.tw.
10
Marine Microorganism Ecological and Application Lab, Zhejiang Ocean University, Zhoushan 316004, China. xuem07@163.com.
11
Department of Marine Biotechnology and Resources, National Sun Yat-sen University, 70 Lienhai Rd., Kaohsiung 80424, Taiwan. wzh@mail.nsysu.edu.tw.
12
Graduate Institute of Biomedical Science, China Medical University, Cancer Center Building 8F, No. 6, Hsueh-shih Road, Taichung 40477, Taiwan. yahuey@mail.cmu.edu.tw.
13
Center for Molecular Medicine, China Medical University Hospital, Taichung 40477, Taiwan. yahuey@mail.cmu.edu.tw.
14
Cancer Biology and Drug Discovery Ph.D. Program, College of Medicine, China Medical University, Taichung 40477, Taiwan. yahuey@mail.cmu.edu.tw.
15
Department and Graduate Institute of Aquaculture, National Kaohsiung University of Science and Technology, No.142, Haijhuan Rd., Nazih Dist., Kaohsiung 81157, Taiwan. tmtonychen@webmail.nkmu.edu.tw.

Abstract

Benign prostate hyperplasia (BPH) is one of the most common urological problems in mid-aged to elderly men. Risk factors of BPH include family history, obesity, type 2 diabetes, and high oxidative stress. The main medication classes for BPH management are alpha blockers and 5α-reductase inhibitors. However, these conventional medicines cause adverse effects. Lycogen™, extracted from Rhodobacter sphaeroides WL-APD911, is an anti-oxidant and anti-inflammatory compound. In this study, the effect of Lycogen™ was evaluated in rats with testosterone-induced benign prostate hyperplasia (BPH). Testosterone injections and Lycogen™ administration were carried out for 28 days, and body weights were recorded twice per week. The testosterone injection successfully induced a prostate enlargement. BPH-induced rats treated with different doses of Lycogen™ exhibited a significantly decreased prostate index (PI). Moreover, the Lycogen™ administration recovered the histological abnormalities observed in the prostate of BPH rats. In conclusion, these findings support a dose-dependent preventing effect of Lycogen™ on testosterone-induced BPH in rats and suggest that Lycogen™ may be favorable to the prevention and management of benign prostate hyperplasia.

KEYWORDS:

Lycogen™; Rhodobacter sphaeroides; benign prostate hyperplasia; probiotics

PMID:
29642620
PMCID:
PMC5979474
DOI:
10.3390/ijms19041137
[Indexed for MEDLINE]
Free PMC Article

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