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Page 1
Improved PIEZO1 agonism through 4-benzoic acid modification of Yoda1.
Parsonage G, Cuthbertson K, Endesh N, Murciano N, Hyman AJ, Revill CH, Povstyan OV, Chuntharpursat-Bon E, Debant M, Ludlow MJ, Futers TS, Lichtenstein L, Kinsella JA, Bartoli F, Rotordam MG, Becker N, Brüggemann A, Foster R, Beech DJ. Parsonage G, et al. Among authors: revill ch. Br J Pharmacol. 2023 Aug;180(16):2039-2063. doi: 10.1111/bph.15996. Epub 2023 Jan 31. Br J Pharmacol. 2023. PMID: 36457143 Free PMC article.
Structure-Based Design of Potent and Orally Active Isoindolinone Inhibitors of MDM2-p53 Protein-Protein Interaction.
Chessari G, Hardcastle IR, Ahn JS, Anil B, Anscombe E, Bawn RH, Bevan LD, Blackburn TJ, Buck I, Cano C, Carbain B, Castro J, Cons B, Cully SJ, Endicott JA, Fazal L, Golding BT, Griffin RJ, Haggerty K, Harnor SJ, Hearn K, Hobson S, Holvey RS, Howard S, Jennings CE, Johnson CN, Lunec J, Miller DC, Newell DR, Noble MEM, Reeks J, Revill CH, Riedinger C, St Denis JD, Tamanini E, Thomas H, Thompson NT, Vinković M, Wedge SR, Williams PA, Wilsher NE, Zhang B, Zhao Y. Chessari G, et al. Among authors: revill ch. J Med Chem. 2021 Apr 8;64(7):4071-4088. doi: 10.1021/acs.jmedchem.0c02188. Epub 2021 Mar 24. J Med Chem. 2021. PMID: 33761253
An in vivo platform for identifying inhibitors of protein aggregation.
Saunders JC, Young LM, Mahood RA, Jackson MP, Revill CH, Foster RJ, Smith DA, Ashcroft AE, Brockwell DJ, Radford SE. Saunders JC, et al. Among authors: revill ch. Nat Chem Biol. 2016 Feb;12(2):94-101. doi: 10.1038/nchembio.1988. Epub 2015 Dec 14. Nat Chem Biol. 2016. PMID: 26656088 Free PMC article.
MDM2-p53 protein-protein interaction inhibitors: a-ring substituted isoindolinones.
Watson AF, Liu J, Bennaceur K, Drummond CJ, Endicott JA, Golding BT, Griffin RJ, Haggerty K, Lu X, McDonnell JM, Newell DR, Noble ME, Revill CH, Riedinger C, Xu Q, Zhao Y, Lunec J, Hardcastle IR. Watson AF, et al. Among authors: revill ch. Bioorg Med Chem Lett. 2011 Oct 1;21(19):5916-9. doi: 10.1016/j.bmcl.2011.07.084. Epub 2011 Aug 9. Bioorg Med Chem Lett. 2011. PMID: 21875801
Isoindolinone inhibitors of the murine double minute 2 (MDM2)-p53 protein-protein interaction: structure-activity studies leading to improved potency.
Hardcastle IR, Liu J, Valeur E, Watson A, Ahmed SU, Blackburn TJ, Bennaceur K, Clegg W, Drummond C, Endicott JA, Golding BT, Griffin RJ, Gruber J, Haggerty K, Harrington RW, Hutton C, Kemp S, Lu X, McDonnell JM, Newell DR, Noble ME, Payne SL, Revill CH, Riedinger C, Xu Q, Lunec J. Hardcastle IR, et al. Among authors: revill ch. J Med Chem. 2011 Mar 10;54(5):1233-43. doi: 10.1021/jm1011929. Epub 2011 Feb 11. J Med Chem. 2011. PMID: 21314128