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Anticancer Res. 2015 May;35(5):2493-501.

Randomized Trials of Systemic Medically-treated Malignant Mesothelioma: A Systematic Review.

Author information

1
Department of Oncology, Gävle Hospital, Gävle, Sweden Centre for Research and Development Uppsala University/County Council of Gävleborg, Uppsala, Sweden Department of Radiation Sciences and Oncology, Umeå University Hospital, Umeå, Sweden.
2
Department of Oncology, Gävle Hospital, Gävle, Sweden Centre for Research and Development Uppsala University/County Council of Gävleborg, Uppsala, Sweden Department of Radiology, Oncology and Radiation Sciences, Uppsala University Hospital, Uppsala, Sweden.
3
Department of Oncology, Gävle Hospital, Gävle, Sweden.
4
Department of Surgery, Uppsala University Hospital, Uppsala, Sweden.
5
Department of Oncology, Uppsala University Hospital, Uppsala, Sweden.
6
Department of Oncology, Gävle Hospital, Gävle, Sweden Department of Oncology, Uppsala University Hospital, Uppsala, Sweden Department of Radiation Sciences and Oncology, Umeå University Hospital, Umeå, Sweden stefan.bergstrom@regiongavleborg.se.

Abstract

Malignant pleural mesothelioma (MPM) is a rare but aggressive malignancy mainly localized to the pleura. Malignant mesothelioma grows highly invasive into surrounding tissue and has a low tendency to metastasize. The median overall survival (OS) of locally advanced or metastatic disease without treatment is 4-13 months but, during recent years, improvement in survival has been achieved since treatment for patients with mesothelioma has improved with better palliative care, systemic medical treatment, surgery and improved diagnostics methods. The present review aims at describing available data from randomized trials considering systemic medical treatment for this patient category.

KEYWORDS:

Malignant mesothelioma; randomized trials; review

PMID:
25964522
[Indexed for MEDLINE]

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