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Reumatol Clin. 2016 Jul-Aug;12(4):210-5. doi: 10.1016/j.reuma.2016.01.001. Epub 2016 Feb 18.

Rituximab in lupus nephritis: A non-systematic review.

[Article in English, Spanish]

Author information

1
Unidad de Enfermedades Reumáticas y Autoinmunes (UNERA), Guayaquil, Ecuador; Facultad de Ciencias Médicas, Universidad Espíritu Santo, Guayaquil, Ecuador.
2
Facultad de Ciencias Médicas, Universidad Espíritu Santo, Guayaquil, Ecuador. Electronic address: aldocosva_01@hotmail.com.

Abstract

Lupus nephritis (LN) is a common and severe complication in patients with lupus. Current therapy is based on immunosuppressive drugs and glucocorticoids. Recently, rituximab has been proposed as an alternative treatment for LN. Rituximab is a monoclonal antibody directed against the CD20 antigen receptor on B cells. The aim of this review is to summarize all the available information about rituximab in LN. Eleven studies were found; three of them were observational studies (2 prospective and 1 retrospective) and eight were clinical trials (7 open-label studies and only 1 randomized controlled trial [RCT]). The evidence is insufficient to establish the role of rituximab in the treatment of LN. Results from the only RCT, which were negative, suggest a clinical benefit in black people. Further studies must confirm this hypothesis. Controlled clinical trials involving adaptive randomization are required to establish the real benefit of rituximab in LN.

KEYWORDS:

Lupus; Nefritis; Nephritis; Rituximab

PMID:
26906063
DOI:
10.1016/j.reuma.2016.01.001
[Indexed for MEDLINE]
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