Format

Send to

Choose Destination

See 1 citation found by title matching your search:

J Invest Dermatol. 2018 Aug;138(8):1754-1763. doi: 10.1016/j.jid.2018.02.030. Epub 2018 Mar 3.

Resident T Cells in Resolved Psoriasis Steer Tissue Responses that Stratify Clinical Outcome.

Author information

1
Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden; Department of Dermatology, Karolinska University Hospital, Stockholm, Sweden.
2
Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden.
3
Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden.
4
Department of Cell and Molecular Biology Karolinska Institutet, Stockholm, Sweden.
5
Department of Reconstructive Plastic Surgery, Karolinska University Hospital Solna, Stockholm, Sweden.
6
Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden; Department of Dermatology, Karolinska University Hospital, Stockholm, Sweden. Electronic address: liv.eidsmo@ki.se.

Abstract

Psoriasis is driven by focal disruptions of the immune-homeostasis in human skin. Local relapse following cessation of therapy is common and unpredictable, which complicates clinical management of psoriasis. We have previously shown that pathogenic resident T cells accumulate in active and resolved psoriasis, but whether these cells drive psoriasiform tissue reactions is less clear. Here, we activated T cells within skin explants using the pan-T cell activating antibody OKT-3. To explore if T cells induced different tissue response patterns in healthy and psoriasis afflicted skin, transcriptomic analyses were performed with RNA-sequencing and Nanostring. Core tissue responses dominated by IFN-induced pathways were triggered regardless of the inflammatory status of the skin. In contrast, pathways induced by IL-17A, including Defensin beta 2 and keratinocyte differentiation markers, were activated in psoriasis samples. An integrated analysis of IL-17A and IFN-related responses revealed that IL-17 dominated tissue response correlated with early relapse following UVB treatment. Stratification of tissue responses to T cell activation in resolved lesions could potentially offer individualized prediction of disease relapse during long-term immunomodulatory treatment.

PMID:
29510191
DOI:
10.1016/j.jid.2018.02.030
[Indexed for MEDLINE]
Free full text

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center