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Reprod Sci. 2013 Oct;20(10):1230-6. doi: 10.1177/1933719113483014. Epub 2013 Mar 27.

Regression of endometrial implants by resveratrol in an experimentally induced endometriosis model in rats.

Author information

1
1Department of Obstetrics and Gynaecology, Ege University School of Medicine, Izmir, Turkey.

Abstract

OBJECTIVE:

To evaluate the effect of resveratrol on an experimentally induced endometriosis rat model.

STUDY DESIGN:

After endometriotic implants were surgically formed, rats were randomly divided into 2 groups as control group (saline treated, n = 6) and resveratrol group (10 mg/kg/d, n = 6). The inflammatory markers and histopathological changes were assessed at the end of the treatment period. Results Our results showed (1) significant reduction in the implant size (P < .0005); (2) significantly decreased levels of vascular endothelial growth factor (VEGF) in the peritoneal fluid and plasma (P < .005); and monocyte chemotactic protein 1 (MCP-1) in the peritoneal fluid (P < .05), (3) highly significant suppression of VEGF expression in the endometriotic tissue (P < .0005); and (4) considerable histological changes in the endometriotic foci following resveratrol treatment.

CONCLUSION:

Resveratrol appears to be effective on the development of endometriosis through its antiangiogenic and anti-inflammatory properties. Future studies with different doses of resveratrol might provide more comprehensive results regarding the treatment of endometriosis.

KEYWORDS:

MCP-1; TNF-α; VEGF; cytokines; endometriosis; resveratrol

PMID:
23536571
DOI:
10.1177/1933719113483014
[Indexed for MEDLINE]

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