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Front Immunol. 2015 Aug 20;6:412. doi: 10.3389/fimmu.2015.00412. eCollection 2015.

Report of the First International Consensus on Standardized Nomenclature of Antinuclear Antibody HEp-2 Cell Patterns 2014-2015.

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Department of Oral Biology, University of Florida , Gainesville, FL , USA.
Central Diagnostic Laboratory, Maastricht University Medical Center , Maastricht , Netherlands.
Laboratory of Immunology, Hospital Carlos G. Durand , Buenos Aires , Argentina ; Department of Immunology, Instituto Universitario del Hospital Italiano , Buenos Aires , Argentina.
Institute of Immunology, Technical University of Dresden , Dresden , Germany.
Pontifícia Universidade Católica de Goiás , Goiânia , Brazil.
Department of Medicine, Cumming School of Medicine, University of Calgary , Calgary, AB , Canada.
Department of Immunology and Rheumatology, Hospital General de Occidente, University of Guadalajara , Guadalajara , Mexico.
Department of Internal Medicine VI, Medical University of Innsbruck , Innsbruck , Austria.
Department of the Control for Rheumatic Diseases, Graduate School of Medicine, Kyoto University , Kyoto , Japan ; Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University , Kyoto , Japan.
Department of Clinical Nursing, University of Occupational and Environmental Health , Kitakyushu , Japan.
Brazilian Society of Autoimmunity , Porto Alegre , Brazil.
Rheumatology Division, Escola Paulista de Medicina, Universidade Federal de São Paulo , São Paulo , Brazil ; Immunology Division, Fleury Medicine and Health Laboratories , São Paulo , Brazil.


During the 12th International Workshop on Autoantibodies and Autoimmunity held in Sao Paulo, Brazil, on August 28, 2014, a full day session was devoted to establishing a consensus on the nomenclature of staining patterns observed in the antinuclear antibody (ANA) indirect immunofluorescence test on HEp-2 cells. The current report summarizes the collective agreements with input from the host Brazilian and international communities that represented research, clinical, and diagnostic service laboratories. Patterns are categorized in three major groups (nuclear, cytoplasmic, and mitotic patterns) and each pattern has been defined and described in detail. The consensus nomenclature and representative patterns are made available online at the international consensus on antinuclear antibody pattern (ICAP) website ( To facilitate continuous improvement and input, specific comments on ICAP are encouraged and these will be discussed in subsequent ICAP meetings. The ultimate goal with the establishment of the ICAP is to promote harmonization and understanding of autoantibody test nomenclature, as well as interpretation guidelines for ANA testing, thereby optimizing usage in patient care.


antinuclear antibodies; autoantibody; autoimmunity; consensus; standardization

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