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Neuroimage. 2013 Feb 1;66:161-8. doi: 10.1016/j.neuroimage.2012.10.014. Epub 2012 Oct 13.

Relationship between fractional anisotropy of cerebral white matter and metabolite concentrations measured using (1)H magnetic resonance spectroscopy in healthy adults.

Author information

1
Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD, USA.
2
Aerospace Medicine Consultation Division, Dayton, OH, USA.
3
Department of Neuroradiology, Wilford Hall Ambulatory Surgical Center, San Antonio, TX, USA.
4
Research Imaging Institute, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA.
5
Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD, USA; Department of Physics, University of Maryland Baltimore County (UMBC), MD, USA.
6
Department of Psychiatry, Yale University and Olin Neuropsychiatric Research Center, Hartford, CT, USA.
7
Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD, USA; Department of Physics, University of Maryland Baltimore County (UMBC), MD, USA. Electronic address: pkochunov@mprc.umaryland.edu.

Abstract

Fractional anisotropy (FA) of water diffusion in cerebral white matter (WM), derived from diffusion tensor imaging (DTI), is a sensitive index of microscopic WM integrity. Physiological and metabolic factors that explain intersubject variability in FA values were evaluated in two cohorts of healthy adults of different age spans (N=65, range: 28-50years; and N=25, age=66.6±6.2, range: 57-80years). Single voxel magnetic resonance spectroscopy (MRS) was used to measure N-acetylaspartate (NAA), total choline-containing compounds, and total creatine, bilaterally in an associative WM tract: anterior corona radiata (ACR). FA values were calculated for the underlying, proximal and two distal WM regions. Two-stage regression analysis was used to calculate the proportion of variability in FA values explained by spectroscopy measurements, at the first stage, and subject's age, at the second stage. WM NAA concentration explained 23% and 66% of intersubject variability (p<0.001) in the FA of the underlying WM in the younger and older cohorts, respectively. WM NAA concentration also explained a significant proportion of variability in FA of the genu of corpus callosum (CC), a proximal WM tract where some of the fibers contained within the spectroscopic voxel decussate. NAA concentrations also explained a significant proportion of variability in the FA values in the splenium of CC, a distal WM tract that also carries associative fibers, in both cohorts. These results suggest that MRS measurements explained a significant proportion of variability in FA values in both proximal and distal WM tracts that carry similar fiber-types.

KEYWORDS:

Diffusion tensor imaging; Magnetic resonance spectroscopy; N-acetylaspartate; White matter

PMID:
23073233
PMCID:
PMC3779655
DOI:
10.1016/j.neuroimage.2012.10.014
[Indexed for MEDLINE]
Free PMC Article

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