Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

Filters

My NCBI Filters

Results by year

Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1995 2
1996 5
1997 3
1998 4
1999 7
2000 4
2001 5
2002 10
2003 15
2004 12
2005 12
2006 14
2007 15
2008 22
2009 27
2010 20
2011 38
2012 15
2013 30
2014 22
2015 18
2016 18
2017 20
2018 22
2019 25
2020 22
2021 17
2022 23
2023 17
2024 8

Text availability

Article attribute

Article type

Publication date

Search Results

417 results

Results by year

Citations

1 article found by citation matching

Search results

Filters applied: . Clear all
Page 1
Sirt6 attenuates chondrocyte senescence and osteoarthritis progression.
Ji ML, Jiang H, Li Z, Geng R, Hu JZ, Lin YC, Lu J. Ji ML, et al. Nat Commun. 2022 Dec 10;13(1):7658. doi: 10.1038/s41467-022-35424-w. Nat Commun. 2022. PMID: 36496445 Free PMC article.
Here we show that Sirt6 deficiency exaggerates chondrocyte senescence and osteoarthritis progression, whereas intra-articular injection of adenovirus-Sirt6 markedly attenuates surgical destabilization of medial meniscus-induced osteoarthritis. Mechanistically, Sirt6 can di …
Here we show that Sirt6 deficiency exaggerates chondrocyte senescence and osteoarthritis progression, whereas intra-articular injection of a …
Crosstalk between IL-15Rα+ tumor-associated macrophages and breast cancer cells reduces CD8+ T cell recruitment.
Zhang W, Zhang Q, Yang N, Shi Q, Su H, Lin T, He Z, Wang W, Guo H, Shen P. Zhang W, et al. Cancer Commun (Lond). 2022 Jun;42(6):536-557. doi: 10.1002/cac2.12311. Epub 2022 May 25. Cancer Commun (Lond). 2022. PMID: 35615815 Free PMC article.
BACKGROUND: Interleukin-15 (IL-15) is a promising immunotherapeutic agent owing to its powerful immune-activating effects. ...RESULTS: We found that macrophages contributed to the resistance of tumor cells to IL-15, and tumor cells …
BACKGROUND: Interleukin-15 (IL-15) is a promising immunotherapeutic agent owing to its powerful immune-activatin …
Heterodimeric IL-15 delays tumor growth and promotes intratumoral CTL and dendritic cell accumulation by a cytokine network involving XCL1, IFN-gamma, CXCL9 and CXCL10.
Bergamaschi C, Pandit H, Nagy BA, Stellas D, Jensen SM, Bear J, Cam M, Valentin A, Fox BA, Felber BK, Pavlakis GN. Bergamaschi C, et al. J Immunother Cancer. 2020 May;8(1):e000599. doi: 10.1136/jitc-2020-000599. J Immunother Cancer. 2020. PMID: 32461349 Free PMC article.
BACKGROUND: Interleukin-15 (IL-15) promotes growth and activation of cytotoxic CD8(+) T and natural killer (NK) cells. Bioactive IL-15 is produced in the body as a heterodimeric cytokine, comprising the IL-15 and IL- …
BACKGROUND: Interleukin-15 (IL-15) promotes growth and activation of cytotoxic CD8(+) T and natural killer (NK) …
Tumor immune contexture is a determinant of anti-CD19 CAR T cell efficacy in large B cell lymphoma.
Scholler N, Perbost R, Locke FL, Jain MD, Turcan S, Danan C, Chang EC, Neelapu SS, Miklos DB, Jacobson CA, Lekakis LJ, Lin Y, Ghobadi A, Kim JJ, Chou J, Plaks V, Wang Z, Xue A, Mattie M, Rossi JM, Bot A, Galon J. Scholler N, et al. Nat Med. 2022 Sep;28(9):1872-1882. doi: 10.1038/s41591-022-01916-x. Epub 2022 Aug 29. Nat Med. 2022. PMID: 36038629 Free PMC article.
TME enriched for chemokines (CCL5 and CCL22), gamma-chain receptor cytokines (IL-15, IL-7 and IL-21) and interferon-regulated molecules were associated with T cell infiltration and markers of activity. Finally, high density of regulatory T cells in pre-treatm …
TME enriched for chemokines (CCL5 and CCL22), gamma-chain receptor cytokines (IL-15, IL-7 and IL-21) and interferon-regulated …
Immunomodulatory Effects of IL-2 and IL-15; Implications for Cancer Immunotherapy.
Yang Y, Lundqvist A. Yang Y, et al. Cancers (Basel). 2020 Nov 30;12(12):3586. doi: 10.3390/cancers12123586. Cancers (Basel). 2020. PMID: 33266177 Free PMC article. Review.
The type I cytokine family members interleukin-2 (IL-2) and IL-15 play important roles in the homeostasis of innate and adaptive immunity. ...While IL-2 expands regulatory T cells and CD4+ helper T cells, IL-15 supports the development of centra …
The type I cytokine family members interleukin-2 (IL-2) and IL-15 play important roles in the homeostasis of innate and adapti …
The role of interleukin 15 in neoplasia.
Chłopek M, Kowalik A, Góźdź S, Koziak K. Chłopek M, et al. Postepy Hig Med Dosw (Online). 2017 Jan 10;71(0):5-19. doi: 10.5604/17322693.1228266. Postepy Hig Med Dosw (Online). 2017. PMID: 28181907 Review.
At the same time, IL-15 protects effector cells from T regulatory cells and does not induce immune tolerance. The significant regulatory action of IL-15 on the immune system provides new opportunities for development of anti-cancer …
At the same time, IL-15 protects effector cells from T regulatory cells and does not induce immune tolerance. Th …
Attenuation of Allergen-, IL-13-, and TGF-alpha-induced Lung Fibrosis after the Treatment of rIL-15 in Mice.
Upparahalli Venkateshaiah S, Niranjan R, Manohar M, Verma AK, Kandikattu HK, Lasky JA, Mishra A. Upparahalli Venkateshaiah S, et al. Am J Respir Cell Mol Biol. 2019 Jul;61(1):97-109. doi: 10.1165/rcmb.2018-0254OC. Am J Respir Cell Mol Biol. 2019. PMID: 30702923 Free PMC article.
Endogenous IL-15 deficiency promotes lung fibrosis; therefore, we examined the effect of induced IL-15 in restricting the progression of lung fibrosis. ...Additionally, to establish that the antifibrotic effect of IL-15
Endogenous IL-15 deficiency promotes lung fibrosis; therefore, we examined the effect of induced IL-15
Effects of three IL-15 variants on NCI-H446 cell proliferation and expression of cell cycle regulatory molecules.
Ding JY, Wang ZH, Zhang ZZ, Cui XR, Hong YY, Liu QQ. Ding JY, et al. Oncotarget. 2017 Nov 20;8(64):108108-108117. doi: 10.18632/oncotarget.22550. eCollection 2017 Dec 8. Oncotarget. 2017. PMID: 29296227 Free PMC article.
Interleukin 15 (IL-15) is a cytokine exhibiting antitumor characteristic similar to that of IL-2. ...In the present study, we assessed the effects of transfecting NCI-H446 small cell lung cancer cells with genes encoding three IL-15
Interleukin 15 (IL-15) is a cytokine exhibiting antitumor characteristic similar to that of IL-2. ...In the pres
Prospect of IL-2, IL-7, IL-15 and IL-21 for HIV immune-based therapy.
Diallo M, Zheng Y, Chen X, He Y, Zhou H, Chen Z. Diallo M, et al. Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2011 Nov;36(11):1037-45. doi: 10.3969/j.issn.1672-7347.2011.11.002. Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2011. PMID: 22169717 Review.
The common gamma-chain cytokines IL-2, IL-7, IL-15, and IL-21 are primary regulators of T cell homeostasis and thus have been considered prime immunotherapeutic candidates, both for increasing T cell levels/function and augmenting vaccine-elicited viral-specific T c …
The common gamma-chain cytokines IL-2, IL-7, IL-15, and IL-21 are primary regulators of T cell homeostasis and thus have been …
Immune and inflammatory mechanisms in hypertension.
Guzik TJ, Nosalski R, Maffia P, Drummond GR. Guzik TJ, et al. Nat Rev Cardiol. 2024 Jan 3. doi: 10.1038/s41569-023-00964-1. Online ahead of print. Nat Rev Cardiol. 2024. PMID: 38172242 Review.
Neoantigens, the NLRP3 inflammasome and increased sympathetic outflow, as well as cytokines (including IL-6, IL-7, IL-15, IL-18 and IL-21) and a high-salt environment, can contribute to immune activation in hypertension. ...A comprehensive understanding of the immun …
Neoantigens, the NLRP3 inflammasome and increased sympathetic outflow, as well as cytokines (including IL-6, IL-7, IL-15, IL-1 …
417 results