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Am J Clin Nutr. 2011 Apr;93(4):884S-90. doi: 10.3945/ajcn.110.001917. Epub 2011 Feb 2.

Regulation of PGC-1α, a nodal regulator of mitochondrial biogenesis.

Author information

1
Laboratory for Integrative and Systems Physiology, Ecole Polytechnique Fédérale de Lausanne, Switzerland.

Abstract

Mechanisms responsible for energy management in the cell and in the whole organism require a complex network of transcription factors and cofactors. Peroxisome proliferator-activated receptor γ coactivator 1α (PGC-1α) has emerged as a master regulator of mitochondrial biogenesis and function, thus becoming a crucial metabolic node. We present an overview of the mechanisms by which PGC-1α is regulated, including the transcriptional regulation of PGC-1α expression and the fine-tuning of its final activity via posttranslational modifications.

PMID:
21289221
PMCID:
PMC3057551
DOI:
10.3945/ajcn.110.001917
[Indexed for MEDLINE]
Free PMC Article

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