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Acta Pharmacol Sin. 2014 Mar;35(3):316-30. doi: 10.1038/aps.2013.155. Epub 2014 Jan 27.

Recent progress regarding the bioactivities, biosynthesis and synthesis of naturally occurring resorcinolic macrolides.

Author information

1
1] College of Science, China University of Petroleum, Qingdao 266580, China [2] Weifang Biomedical Innovation and Entrepreneurship Service Center, Weifang 261205, China.
2
State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.
3
College of Science, China University of Petroleum, Qingdao 266580, China.
4
Weifang Biomedical Innovation and Entrepreneurship Service Center, Weifang 261205, China.

Abstract

Macrolides, which comprise a family of lactones with different ring sizes, belong to the polyketide class of natural products. Resorcinolic macrolides, an important subgroup, possess interesting structures and exhibit a wide variety of bioactivities, such as anti-tumor, anti-bacteria, and anti-malaria activities, etc. This review summarizes progress in isolation, bioactivity studies, biosynthesis, and representative chemical syntheses of this group of macrolides in recent decades, encompassing 63 naturally occurring macrolides published in 120 articles.

PMID:
24464049
PMCID:
PMC4647893
DOI:
10.1038/aps.2013.155
[Indexed for MEDLINE]
Free PMC Article

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