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J Magn Reson Imaging. 2016 Sep;44(3):683-97. doi: 10.1002/jmri.25208. Epub 2016 Mar 10.

Realistic aortic phantom to study hemodynamics using MRI and cardiac catheterization in normal and aortic coarctation conditions.

Author information

1
School of Medicine, Pontificia Universidad Católica de Chile, Santiago, Chile.
2
Biomedical Imaging Center, Pontificia Universidad Católica de Chile, Santiago, Chile.
3
Electrical Engineering Department, Pontificia Universidad Católica de Chile, Santiago, Chile.
4
Structural and Geotechnical Engineering Department, Pontificia Universidad Católica de Chile, Santiago, Chile.
5
Pediatric Cardiology Unit, School of Medicine, Pontificia Universidad Católica de Chile, Santiago, Chile.
6
Radiology Department, School of Medicine, Pontificia Universidad Católica de Chile, Santiago, Chile.
7
Division of Imaging Sciences, King's College London, London, UK.
8
Pediatric Cardiology Unit, Hospital Virgen del Rocio, Universidad de Sevilla, Seville, Spain.
9
Institute of Biomedicine of Seville, Universidad de Sevilla, Seville, Spain.

Abstract

PURPOSE:

To design and characterize a magnetic resonance imaging (MRI)-compatible aortic phantom simulating normal and aortic coarctation (AoCo) conditions and to compare its hemodynamics with healthy volunteers and AoCo patients.

MATERIALS AND METHODS:

The phantom is composed of an MRI-compatible pump, control unit, aortic model, compliance chamber, nonreturn, and shutoff valves. The phantom without and with AoCo (13, 11, and 9 mm) was studied using 2D and 3D phase-contrast data and with a catheterization unit to measure pressures. The phantom data were compared with the mean values of 10 healthy volunteers and two AoCo patients.

RESULTS:

Hemodynamic parameters in the normal phantom and healthy volunteers were: heart rate: 68/61 bpm, cardiac output: 3.5/4.5 L/min, peak flow and peak velocity (Vpeak) in the ascending aorta (AAo): 270/357 mL/s (significantly, P < 0.05) and 97/107 cm/s (not significantly, P = 0.16), and pressure in the AAo of the normal phantom of 131/58 mmHg. Hemodynamic parameters in the 13, 11, and 9 mm coarctation phantoms and Patients 1 and 2 were: heart rate: 75/75/75/97/78 bpm, cardiac output: 3.3/3.0/2.9/4.0/5.8 L/min, peak flow in the AAo: 245/265/215/244/376 mL/s, Vpeak in the AAo: 96/95/81/196/187 cm/s, Vpeak after the AoCo: 123/187/282/247/165 cm/s, pressure in the AAo: 124/56, 127/51, 133/50, 120/51 and 87/39 mmHg, and a trans-coarctation systolic pressure gradient: 7, 10, 30, 20, and 11 mmHg.

CONCLUSION:

We propose and characterize a normal and an AoCo phantom, whose hemodynamics, including velocity, flow, and pressure data are within the range of healthy volunteers and patients with AoCo. J. Magn. Reson. Imaging 2016;44:683-697.

KEYWORDS:

3D PC-MRI; aortic coarctation; aortic phantom; catheterization; hemodynamic parameters

PMID:
26969867
DOI:
10.1002/jmri.25208
[Indexed for MEDLINE]

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