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Year Number of Results
2016 4
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2020 3
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2024 0

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24 results

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Page 1
Design of rigid protein-protein interaction inhibitors enables targeting of undruggable Mcl-1.
Hargreaves D, Carbajo RJ, Bodnarchuk MS, Embrey K, Rawlins PB, Packer M, Degorce SL, Hird AW, Johannes JW, Chiarparin E, Schade M. Hargreaves D, et al. Among authors: rawlins pb. Proc Natl Acad Sci U S A. 2023 May 23;120(21):e2221967120. doi: 10.1073/pnas.2221967120. Epub 2023 May 15. Proc Natl Acad Sci U S A. 2023. PMID: 37186857 Free PMC article.
Rapid Identification of Novel Allosteric PRC2 Inhibitors.
Read JA, Tart J, Rawlins PB, Gregson C, Jones K, Gao N, Zhu X, Tomlinson R, Code E, Cheung T, Chen H, Kawatkar SP, Bloecher A, Bagal S, O'Donovan DH, Robinson J. Read JA, et al. Among authors: rawlins pb. ACS Chem Biol. 2019 Oct 18;14(10):2134-2140. doi: 10.1021/acschembio.9b00468. Epub 2019 Sep 23. ACS Chem Biol. 2019. PMID: 31525019
Regenerable Biosensors for Small-Molecule Kinetic Characterization Using SPR.
Gunnarsson A, Stubbs CJ, Rawlins PB, Taylor-Newman E, Lee WC, Geschwindner S, Hytönen V, Holdgate G, Jha R, Dahl G. Gunnarsson A, et al. Among authors: rawlins pb. SLAS Discov. 2021 Jun;26(5):730-739. doi: 10.1177/2472555220975358. Epub 2020 Dec 8. SLAS Discov. 2021. PMID: 33289457 Free article.
Fragment screening at AstraZeneca: developing the next generation biophysics fragment set.
Lucas SCC, Börjesson U, Bostock MJ, Cuff J, Edfeldt F, Embrey KJ, Eriksson PO, Gohlke A, Gunnarson A, Lainchbury M, Milbradt AG, Moore R, Rawlins PB, Sinclair I, Stubbs C, Storer RI. Lucas SCC, et al. Among authors: rawlins pb. RSC Med Chem. 2022 Jul 4;13(9):1052-1057. doi: 10.1039/d2md00154c. eCollection 2022 Sep 21. RSC Med Chem. 2022. PMID: 36324499 Free PMC article.
Generating Selective Leads for Mer Kinase Inhibitors-Example of a Comprehensive Lead-Generation Strategy.
Nissink JWM, Bazzaz S, Blackett C, Clark MA, Collingwood O, Disch JS, Gikunju D, Goldberg K, Guilinger JP, Hardaker E, Hennessy EJ, Jetson R, Keefe AD, McCoull W, McMurray L, Olszewski A, Overman R, Pflug A, Preston M, Rawlins PB, Rivers E, Schimpl M, Smith P, Truman C, Underwood E, Warwicker J, Winter-Holt J, Woodcock S, Zhang Y. Nissink JWM, et al. Among authors: rawlins pb. J Med Chem. 2021 Mar 25;64(6):3165-3184. doi: 10.1021/acs.jmedchem.0c01904. Epub 2021 Mar 8. J Med Chem. 2021. PMID: 33683117
Pharmacological inhibition of MERTK induces in vivo retinal degeneration: a multimodal imaging ocular safety assessment.
Hamm G, Maglennon G, Williamson B, Macdonald R, Doherty A, Jones S, Harris J, Blades J, Harmer AR, Barton P, Rawlins PB, Smith P, Winter-Holt J, McMurray L, Johansson J, Fitzpatrick P, McCoull W, Coen M. Hamm G, et al. Among authors: rawlins pb. Arch Toxicol. 2022 Feb;96(2):613-624. doi: 10.1007/s00204-021-03197-8. Epub 2022 Jan 1. Arch Toxicol. 2022. PMID: 34973110 Free PMC article.
Structure Based Design of Non-Natural Peptidic Macrocyclic Mcl-1 Inhibitors.
Johannes JW, Bates S, Beigie C, Belmonte MA, Breen J, Cao S, Centrella PA, Clark MA, Cuozzo JW, Dumelin CE, Ferguson AD, Habeshian S, Hargreaves D, Joubran C, Kazmirski S, Keefe AD, Lamb ML, Lan H, Li Y, Ma H, Mlynarski S, Packer MJ, Rawlins PB, Robbins DW, Shen H, Sigel EA, Soutter HH, Su N, Troast DM, Wang H, Wickson KF, Wu C, Zhang Y, Zhao Q, Zheng X, Hird AW. Johannes JW, et al. Among authors: rawlins pb. ACS Med Chem Lett. 2016 Dec 27;8(2):239-244. doi: 10.1021/acsmedchemlett.6b00464. eCollection 2017 Feb 9. ACS Med Chem Lett. 2016. PMID: 28197319 Free PMC article.
Antibody fragments structurally enable a drug-discovery campaign on the cancer target Mcl-1.
Luptak J, Bista M, Fisher D, Flavell L, Gao N, Wickson K, Kazmirski SL, Howard T, Rawlins PB, Hargreaves D. Luptak J, et al. Among authors: rawlins pb. Acta Crystallogr D Struct Biol. 2019 Nov 1;75(Pt 11):1003-1014. doi: 10.1107/S2059798319014116. Epub 2019 Oct 31. Acta Crystallogr D Struct Biol. 2019. PMID: 31692474 Free PMC article.
24 results