Format

Send to

Choose Destination

See 1 citation found by title matching your search:

J Health Care Poor Underserved. 2017;28(1):248-260. doi: 10.1353/hpu.2017.0020.

Race, Genomics and Chronic Disease: What Patients with African Ancestry Have to Say.

Abstract

BACKGROUND:

Variants of the APOL1 gene increase risk for kidney failure 10-fold, and are nearly exclusively found in people with African ancestry. To translate genomic discoveries into practice, we gathered information about effects and challenges incorporating genetic risk in clinical care.

METHODS:

An academic-community-clinical team tested 26 adults with self-reported African ancestry for APOL1 variants, conducting in-depth interviews about patients' beliefs and attitudes toward genetic testing- before, immediately, and 30 days after receiving test results. We used constant comparative analysis of interview transcripts to identify themes.

RESULTS:

Themes included: Knowledge of genetic risk for kidney failure may motivate providers and patients to take hypertension more seriously, rather than inspiring fatalism or anxiety. Having genetic risk for a disease may counter stereotypes of Blacks as non-adherent or low-literate, rather than exacerbate stereotypes.

CONCLUSION:

Populations most likely to benefit from genomic research can inform strategies for genetic testing and future research.

PMID:
28238999
PMCID:
PMC5577001
DOI:
10.1353/hpu.2017.0020
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Project MUSE Icon for PubMed Central
Loading ...
Support Center