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Mol Biosyst. 2013 Feb 2;9(2):307-17. doi: 10.1039/c2mb25384d. Epub 2012 Dec 18.

Quantitative metabolomic and lipidomic profiling reveals aberrant amino acid metabolism in type 2 diabetes.

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1
Department of Oncology, Lombardi Comprehensive Cancer Center at Georgetown University Medical Center, Washington, DC, USA.

Abstract

Type 2 diabetes (T2DM) is a multi-factorial disease with a complex pathogenic mechanism; however a complete understanding of precise biochemical alterations accompanying the onset and progression of T2DM is lacking. Using a combination of untargeted and targeted metabolomic profiling approach we were able to delineate significantly altered metabolites in the diabetic (T2DM) group. Our results indicate significant perturbations in amino acid metabolism, TCA cycle and glycerol-phospholipid metabolism possibly impacting the overall glucose homeostasis in T2DM. A systems approach offers promise towards identification of clinically relevant markers of T2DM and novel molecular targets to foster drug discovery for effective therapeutic development for diabetes.

PMID:
23247761
DOI:
10.1039/c2mb25384d
[Indexed for MEDLINE]

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