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QRFP administration into the medial hypothalamic nuclei improves memory in rats.
Zagorácz O, Ollmann T, Péczely L, László K, Kovács A, Berta B, Kállai V, Kertes E, Lénárd L. Zagorácz O, et al. Brain Res. 2020 Jan 15;1727:146563. doi: 10.1016/j.brainres.2019.146563. Epub 2019 Nov 22. Brain Res. 2020. PMID: 31765630
Even though several of RFamide peptides have been shown to modify memory and learning processes in different species, almost nothing is known regarding cognitive effects of recently discovered neuropeptide QRFP. Considering multiple physiological functions of QRFP, …
Even though several of RFamide peptides have been shown to modify memory and learning processes in different species, almost nothing is know …
QRFP-26 enhances insulin's effects on glucose uptake in rat skeletal muscle cells.
Allerton TD, Primeaux SD. Allerton TD, et al. Peptides. 2015 Jul;69:77-9. doi: 10.1016/j.peptides.2015.04.006. Epub 2015 Apr 18. Peptides. 2015. PMID: 25895849 Free PMC article.
Central administration of QRFP-26 and QRFP-43 induces a macronutrient specific increase in the intake of high fat diet in male and female rats. ...The current experiments were designed to test the hypothesis that QRFP and its receptors, GPR103a and GPR103b ar …
Central administration of QRFP-26 and QRFP-43 induces a macronutrient specific increase in the intake of high fat diet in male …
The hypothalamic neuropeptide, QRFP, regulates high fat diet intake in female Long-Evans rats following ovariectomy.
Martin CT, Primeaux SD. Martin CT, et al. Peptides. 2023 Apr;162:170960. doi: 10.1016/j.peptides.2023.170960. Epub 2023 Jan 21. Peptides. 2023. PMID: 36690209 Free PMC article.
When administered prior to EB treatment, QRFP-26 increased HFD intake. EB treatment attenuated the effects of QRFP-26 on HFD intake. Sub-chronic, continuous administration of QRFP-26 increased HFD intake and weight gain following OVX. Subchronic, continuous a …
When administered prior to EB treatment, QRFP-26 increased HFD intake. EB treatment attenuated the effects of QRFP-26 on HFD i …
The hypothalamic RFamide, QRFP, increases feeding and locomotor activity: The role of Gpr103 and orexin receptors.
Cook C, Nunn N, Worth AA, Bechtold DA, Suter T, Gackeheimer S, Foltz L, Emmerson PJ, Statnick MA, Luckman SM. Cook C, et al. PLoS One. 2022 Oct 17;17(10):e0275604. doi: 10.1371/journal.pone.0275604. eCollection 2022. PLoS One. 2022. PMID: 36251705 Free PMC article.
Germline knock out of either of the mouse QRFP receptor orthologs, Gpr103a and Gpr103b, did not produce a metabolic phenotype. However, both receptors are required for the effect of centrally administered QRFP to increase feeding and locomotor activity. As central i …
Germline knock out of either of the mouse QRFP receptor orthologs, Gpr103a and Gpr103b, did not produce a metabolic phenotype. Howeve …
QRFP and Its Receptors Regulate Locomotor Activity and Sleep in Zebrafish.
Chen A, Chiu CN, Mosser EA, Kahn S, Spence R, Prober DA. Chen A, et al. J Neurosci. 2016 Feb 10;36(6):1823-40. doi: 10.1523/JNEUROSCI.2579-15.2016. J Neurosci. 2016. PMID: 26865608 Free PMC article.
Despite the restriction of these phenotypes to the day, the circadian clock does not regulate qrfp expression, and entrained circadian rhythms are not required for QRFP-induced rest. ...We also show that QRFP overexpression reduces locomotor activity, whereas …
Despite the restriction of these phenotypes to the day, the circadian clock does not regulate qrfp expression, and entrained circadia …
Ontogeny of QRFP and its receptor expression in mouse testis during post-natal development.
Patel SK, Singh SK. Patel SK, et al. Int J Biol Macromol. 2019 Feb 1;122:1217-1223. doi: 10.1016/j.ijbiomac.2018.09.073. Epub 2018 Sep 13. Int J Biol Macromol. 2019. PMID: 30219516
Expression of QRFP and its receptor was high during the early periods of post-natal development. ...A shift in the germ cell types expressing QRFP and its receptor along the course of testicular development and also a prominent immunoreactivity of QRFP in ger …
Expression of QRFP and its receptor was high during the early periods of post-natal development. ...A shift in the germ cell types ex …
Pyroglutamylated RFamide peptide (QRFP): Role in early testicular development in relation to Sertoli cell maturation in prepubertal mice.
Patel SK, Singh SK. Patel SK, et al. Neuropeptides. 2022 Feb;91:102215. doi: 10.1016/j.npep.2021.102215. Epub 2021 Dec 3. Neuropeptides. 2022. PMID: 34883413
QRFP was injected intraperitoneally to male mice from postnatal day 5 to 16. ...QRFP treatment also caused an increase in c-Kit expression in treated mice compared to controls, suggesting an accelerated spermatogonial differentiation in testis of QRFP-treated …
QRFP was injected intraperitoneally to male mice from postnatal day 5 to 16. ...QRFP treatment also caused an increase in c-Ki …
The 26RFa (QRFP)/GPR103 neuropeptidergic system: A key regulator of energy and glucose metabolism.
Devère M, Takhlidjt S, Prévost G, Chartrel N, Leprince J, Picot M. Devère M, et al. Neuroendocrinology. 2024 Apr 10. doi: 10.1159/000538629. Online ahead of print. Neuroendocrinology. 2024. PMID: 38599200 Review.
A new concept has thus emerged, suggesting that obesity and diabetes could be due to a dysfunction of the same, still poorly understood, neural networks. SUMMARY: The neuropeptide 26RFa (also termed QRFP) belongs to the family of RFamide regulatory peptides and has been id …
A new concept has thus emerged, suggesting that obesity and diabetes could be due to a dysfunction of the same, still poorly understood, neu …
Pyroglutamylated RF-amide peptide (QRFP) gene is regulated by metabolic endotoxemia.
Jossart C, Mulumba M, Granata R, Gallo D, Ghigo E, Marleau S, Servant MJ, Ong H. Jossart C, et al. Mol Endocrinol. 2014 Jan;28(1):65-79. doi: 10.1210/me.2013-1027. Epub 2013 Jan 1. Mol Endocrinol. 2014. PMID: 24284825 Free PMC article.
The present study investigated the role of metabolic endotoxemia (ME) on QRFP gene regulation. Our results uncovered the expression of QRFP in murine macrophages and cell lines. ...IFN-beta was induced by ME in macrophages. IFN-beta sustainably reduced QRFP e …
The present study investigated the role of metabolic endotoxemia (ME) on QRFP gene regulation. Our results uncovered the expression o …
Hypothalamic QRFP: regulation of food intake and fat selection.
Primeaux SD, Barnes MJ, Braymer HD. Primeaux SD, et al. Horm Metab Res. 2013 Dec;45(13):967-74. doi: 10.1055/s-0033-1353181. Epub 2013 Aug 26. Horm Metab Res. 2013. PMID: 23979792 Free PMC article.
The localization of the peptide precursor has led to the assessment of QRFP on feeding behaviors and the orexigenic effects of QRFP have been detected in mice, rats, and birds. ...QRFP binds to receptors throughout the brain, including regions associated with …
The localization of the peptide precursor has led to the assessment of QRFP on feeding behaviors and the orexigenic effects of QRF …
81 results