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Sci Rep. 2016 Jun 8;6:27494. doi: 10.1038/srep27494.

Purification of Nanoparticles by Size and Shape.

Author information

1
Department of Chemistry, University College London, London, United Kingdom.
2
Department of Biomedical Science, University of Sheffield, Sheffield, United Kingdom.
3
Department of Infection and Immunity, University of Sheffield, Sheffield, United Kingdom.
4
MRC Centre for Developmental and Biomedical Genetics, University of Sheffield, Sheffield, United Kingdom.
5
Department of Chemistry, University of Basel, Basel, Switzerland.
6
London Interdisciplinary Biosciences Consortium, Division of Biosciences, University College London, London, United Kingdom.

Abstract

Producing monodisperse nanoparticles is essential to ensure consistency in biological experiments and to enable a smooth translation into the clinic. Purification of samples into discrete sizes and shapes may not only improve sample quality, but also provide us with the tools to understand which physical properties of nanoparticles are beneficial for a drug delivery vector. In this study, using polymersomes as a model system, we explore four techniques for purifying pre-formed nanoparticles into discrete fractions based on their size, shape or density. We show that these techniques can successfully separate polymersomes into monodisperse fractions.

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