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Items: 1 to 20 of 550

1.

A long-lived Aβ oligomer resistant to fibrillization.

Nick M, Wu Y, Schmidt NW, Prusiner SB, Stöhr J, DeGrado WF.

Biopolymers. 2018 Jan 10. doi: 10.1002/bip.23096. [Epub ahead of print]

PMID:
29319162
2.

Structural heterogeneity and intersubject variability of Aβ in familial and sporadic Alzheimer's disease.

Condello C, Lemmin T, Stöhr J, Nick M, Wu Y, Maxwell AM, Watts JC, Caro CD, Oehler A, Keene CD, Bird TD, van Duinen SG, Lannfelt L, Ingelsson M, Graff C, Giles K, DeGrado WF, Prusiner SB.

Proc Natl Acad Sci U S A. 2018 Jan 23;115(4):E782-E791. doi: 10.1073/pnas.1714966115. Epub 2018 Jan 8.

3.

Familial Parkinson's point mutation abolishes multiple system atrophy prion replication.

Woerman AL, Kazmi SA, Patel S, Aoyagi A, Oehler A, Widjaja K, Mordes DA, Olson SH, Prusiner SB.

Proc Natl Acad Sci U S A. 2018 Jan 9;115(2):409-414. doi: 10.1073/pnas.1719369115. Epub 2017 Dec 26.

4.

Evidence for sortilin modulating regional accumulation of human tau prions in transgenic mice.

Johnson NR, Condello C, Guan S, Oehler A, Becker J, Gavidia M, Carlson GA, Giles K, Prusiner SB.

Proc Natl Acad Sci U S A. 2017 Dec 19;114(51):E11029-E11036. doi: 10.1073/pnas.1717193114. Epub 2017 Dec 4.

5.

A novel vector for transgenesis in the rat CNS.

Lopez TP, Giles K, Dugger BN, Oehler A, Condello C, Krejciova Z, Castaneda JA, Carlson GA, Prusiner SB.

Acta Neuropathol Commun. 2017 Nov 21;5(1):84. doi: 10.1186/s40478-017-0484-y.

6.

Kinetics of Human Mutant Tau Prion Formation in the Brains of 2 Transgenic Mouse Lines.

Woerman AL, Patel S, Kazmi SA, Oehler A, Freyman Y, Espiritu L, Cotter R, Castaneda JA, Olson SH, Prusiner SB.

JAMA Neurol. 2017 Dec 1;74(12):1464-1472. doi: 10.1001/jamaneurol.2017.2822.

PMID:
29059326
7.

MSA prions exhibit remarkable stability and resistance to inactivation.

Woerman AL, Kazmi SA, Patel S, Freyman Y, Oehler A, Aoyagi A, Mordes DA, Halliday GM, Middleton LT, Gentleman SM, Olson SH, Prusiner SB.

Acta Neuropathol. 2018 Jan;135(1):49-63. doi: 10.1007/s00401-017-1762-2. Epub 2017 Aug 28.

8.

A 31-residue peptide induces aggregation of tau's microtubule-binding region in cells.

Stöhr J, Wu H, Nick M, Wu Y, Bhate M, Condello C, Johnson N, Rodgers J, Lemmin T, Acharya S, Becker J, Robinson K, Kelly MJS, Gai F, Stubbs G, Prusiner SB, DeGrado WF.

Nat Chem. 2017 Sep;9(9):874-881. doi: 10.1038/nchem.2754. Epub 2017 Apr 3.

9.

Bioassays and Inactivation of Prions.

Giles K, Woerman AL, Berry DB, Prusiner SB.

Cold Spring Harb Perspect Biol. 2017 Aug 1;9(8). pii: a023499. doi: 10.1101/cshperspect.a023499. Review.

10.

α-Synuclein: Multiple System Atrophy Prions.

Woerman AL, Watts JC, Aoyagi A, Giles K, Middleton LT, Prusiner SB.

Cold Spring Harb Perspect Med. 2018 Jul 2;8(7). pii: a024588. doi: 10.1101/cshperspect.a024588. Review.

11.

β-Amyloid Prions and the Pathobiology of Alzheimer's Disease.

Watts JC, Prusiner SB.

Cold Spring Harb Perspect Med. 2018 May 1;8(5). pii: a023507. doi: 10.1101/cshperspect.a023507. Review.

12.

Experimental Models of Inherited PrP Prion Diseases.

Watts JC, Prusiner SB.

Cold Spring Harb Perspect Med. 2017 Nov 1;7(11). pii: a027151. doi: 10.1101/cshperspect.a027151. Review.

PMID:
28096244
13.

Developing Therapeutics for PrP Prion Diseases.

Giles K, Olson SH, Prusiner SB.

Cold Spring Harb Perspect Med. 2017 Apr 3;7(4). pii: a023747. doi: 10.1101/cshperspect.a023747. Review.

14.

Tau prions from Alzheimer's disease and chronic traumatic encephalopathy patients propagate in cultured cells.

Woerman AL, Aoyagi A, Patel S, Kazmi SA, Lobach I, Grinberg LT, McKee AC, Seeley WW, Olson SH, Prusiner SB.

Proc Natl Acad Sci U S A. 2016 Dec 13;113(50):E8187-E8196. Epub 2016 Nov 28.

15.

Guinea Pig Prion Protein Supports Rapid Propagation of Bovine Spongiform Encephalopathy and Variant Creutzfeldt-Jakob Disease Prions.

Watts JC, Giles K, Saltzberg DJ, Dugger BN, Patel S, Oehler A, Bhardwaj S, Sali A, Prusiner SB.

J Virol. 2016 Oct 14;90(21):9558-9569. Print 2016 Nov 1.

16.

Structural Polymorphism of Alzheimer's β-Amyloid Fibrils as Controlled by an E22 Switch: A Solid-State NMR Study.

Elkins MR, Wang T, Nick M, Jo H, Lemmin T, Prusiner SB, DeGrado WF, Stöhr J, Hong M.

J Am Chem Soc. 2016 Aug 10;138(31):9840-52. doi: 10.1021/jacs.6b03715. Epub 2016 Jul 28.

17.

FoxO3 regulates neuronal reprogramming of cells from postnatal and aging mice.

Ahlenius H, Chanda S, Webb AE, Yousif I, Karmazin J, Prusiner SB, Brunet A, Südhof TC, Wernig M.

Proc Natl Acad Sci U S A. 2016 Jul 26;113(30):8514-9. doi: 10.1073/pnas.1607079113. Epub 2016 Jul 11.

18.

Towards authentic transgenic mouse models of heritable PrP prion diseases.

Watts JC, Giles K, Bourkas ME, Patel S, Oehler A, Gavidia M, Bhardwaj S, Lee J, Prusiner SB.

Acta Neuropathol. 2016 Oct;132(4):593-610. doi: 10.1007/s00401-016-1585-6. Epub 2016 Jun 28.

19.

Optimization of Aryl Amides that Extend Survival in Prion-Infected Mice.

Giles K, Berry DB, Condello C, Dugger BN, Li Z, Oehler A, Bhardwaj S, Elepano M, Guan S, Silber BM, Olson SH, Prusiner SB.

J Pharmacol Exp Ther. 2016 Sep;358(3):537-47. doi: 10.1124/jpet.116.235556. Epub 2016 Jun 17.

20.

Evidence for α-synuclein prions causing multiple system atrophy in humans with parkinsonism.

Prusiner SB, Woerman AL, Mordes DA, Watts JC, Rampersaud R, Berry DB, Patel S, Oehler A, Lowe JK, Kravitz SN, Geschwind DH, Glidden DV, Halliday GM, Middleton LT, Gentleman SM, Grinberg LT, Giles K.

Proc Natl Acad Sci U S A. 2015 Sep 22;112(38):E5308-17. doi: 10.1073/pnas.1514475112. Epub 2015 Aug 31.

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