Protein kinase G from pathogenic mycobacteria promotes survival within macrophages.
Science. 2004.
PMID: 15155913
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M. tuberculosis PknG manipulates host autophagy flux to promote pathogen intracellular survival.
Autophagy. 2022 Mar;18(3):576-594. doi: 10.1080/15548627.2021.1938912. Epub 2021 Jul 7.
Autophagy. 2022.
PMID: 34092182
Free PMC article.
The eukaryotic-type protein kinase G (PknG), one of the eleven eukaryotic type serine-threonine protein kinase (STPK) in Mycobacterium tuberculosis (Mtb), is involved in mycobacterial survival within macrophages, presumably by supp …
The eukaryotic-type protein kinase G (PknG), one of the eleven eukaryotic type serine-threonine protein kinase ( …
Protein kinase G from pathogenic mycobacteria promotes survival within macrophages.
Science. 2004 Jun 18;304(5678):1800-4. doi: 10.1126/science.1099384. Epub 2004 May 20.
Science. 2004.
PMID: 15155913
Pathogenic mycobacteria resist lysosomal delivery after uptake into macrophages, allowing them to survive intracellularly. We found that the eukaryotic-like serine/threonine protein kinase G from pathogenic mycobacteria …
Pathogenic mycobacteria resist lysosomal delivery after uptake into macrophages, allowing them to survive intrac …
Mycobacterium tuberculosis protein kinase G acts as an unusual ubiquitinating enzyme to impair host immunity.
EMBO Rep. 2021 Jun 4;22(6):e52175. doi: 10.15252/embr.202052175. Epub 2021 May 2.
EMBO Rep. 2021.
PMID: 33938130
Free PMC article.
Upon Mycobacterium tuberculosis (Mtb) infection, protein kinase G (PknG), a eukaryotic-type serine-threonine protein kinase (STPK), is secreted into host macrophages to promote intracellular survival of the pathogen. …
Upon Mycobacterium tuberculosis (Mtb) infection, protein kinase G (PknG), a eukaryotic-type serine-threonine …
Survival of pathogenic mycobacteria in macrophages is mediated through autophosphorylation of protein kinase G.
J Bacteriol. 2009 Jul;191(14):4546-54. doi: 10.1128/JB.00245-09. Epub 2009 May 15.
J Bacteriol. 2009.
PMID: 19447903
Free PMC article.
Pathogenic mycobacteria survive within macrophages through the inhibition of phagosome-lysosome fusion. ...However, autophosphorylation was crucial for the capacity of PknG to promote mycobacterial survival within macrophages. Thes …
Pathogenic mycobacteria survive within macrophages through the inhibition of phagosome-lysosome fusion. ...Howev …
Downregulation of protein kinase C-alpha enhances intracellular survival of Mycobacteria: role of PknG.
BMC Microbiol. 2009 Dec 24;9:271. doi: 10.1186/1471-2180-9-271.
BMC Microbiol. 2009.
PMID: 20030858
Free PMC article.
RESULTS: Based on our earlier study, we have extrapolated for the first time that knockdown of PKCalpha, impairs phagocytosis of mycobacteria by macrophages while their intracellular survival is drastically increased. ...The results strongly demonstrate that …
RESULTS: Based on our earlier study, we have extrapolated for the first time that knockdown of PKCalpha, impairs phagocytosis of mycobact …
"It Takes Two to Tango": Role of Neglected Macrophage Manipulators Coronin 1 and Protein Kinase G in Mycobacterial Pathogenesis.
Front Cell Infect Microbiol. 2020 Oct 20;10:582563. doi: 10.3389/fcimb.2020.582563. eCollection 2020.
Front Cell Infect Microbiol. 2020.
PMID: 33194820
Free PMC article.
Review.
Coronin 1, being a cortical protein is transiently recruited to all mycobacteria containing phagosomes, but only pathogenic mycobacteria can retain it on the phagosome, to hinder its maturation. Additionally, mycobacterial infection linked secretion of …
Coronin 1, being a cortical protein is transiently recruited to all mycobacteria containing phagosomes, but only pathogenic …
Deletion of pknG Abates Reactivation of Latent Mycobacterium tuberculosis in Mice.
Antimicrob Agents Chemother. 2021 Mar 18;65(4):e02095-20. doi: 10.1128/AAC.02095-20. Print 2021 Mar 18.
Antimicrob Agents Chemother. 2021.
PMID: 33468473
Free PMC article.
Eradication of tuberculosis (TB), caused by Mycobacterium tuberculosis (Mtb), has been a challenge due to its uncanny ability to survive in a dormant state inside host granulomas for decades. ...Previously, we showed that protein kinase G (PknG) …
Eradication of tuberculosis (TB), caused by Mycobacterium tuberculosis (Mtb), has been a challenge due to its uncanny ability to s …
PknG supports mycobacterial adaptation in acidic environment.
Mol Cell Biochem. 2018 Jun;443(1-2):69-80. doi: 10.1007/s11010-017-3211-x. Epub 2017 Nov 9.
Mol Cell Biochem. 2018.
PMID: 29124568
Eleven eukaryotic like serine-threonine protein kinases (STPKs) are present in Mtb. Protein kinase G (PknG) has been shown to promote mycobacterial survival inside host cells. A homolog of PknG is also present in Mycobacterium …
Eleven eukaryotic like serine-threonine protein kinases (STPKs) are present in Mtb. Protein kinase G (Pkn …
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