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Environ Toxicol Pharmacol. 2017 Sep;54:99-104. doi: 10.1016/j.etap.2017.07.002. Epub 2017 Jul 5.

Protective role of dietary Spirulina platensis against diazinon-induced Oxidative damage in Nile tilapia; Oreochromis niloticus.

Author information

1
Department of Internal medicine, Infectious and Fish Diseases, Faculty of Veterinary Medicine, Mansoura University, Egypt.
2
Department of Fish Diseases and Management, Faculty of Veterinary Medicine, Suez Canal University, Ismailia 41522, Egypt.
3
Department of Pharmacology, Faculty of Veterinary Medicine, Suez Canal University, Ismailia 41522, Egypt.
4
Department of Clinical Pathology, Faculty of Veterinary Medicine, Suez Canal University, Ismailia 41522, Egypt.
5
Department of Biochemistry, Faculty of Veterinary Medicine, Mansoura University, Egypt.
6
Department of Animal Production, Faculty of Agriculture, Kafrelsheikh University, Kafrelsheikh 33516, Egypt.
7
Department of Hygiene, Faculty of Veterinary Medicine, Suez Canal University, Ismailia 41522, Egypt.
8
Department of Pharmacology, Faculty of Veterinary Medicine, Suez Canal University, Ismailia 41522, Egypt. Electronic address: abdeldaim.m@vet.suez.edu.eg.

Abstract

The current study was performed to investigate the ameliorating effect of dietary supplementation of 0.5 and 1% Spiurolina platensis (SP) diet against the sub-acute toxicity of diazinon (DZN) 0.28mg/L in Nile tilapia. At the end of experiment after 28days, hepatic and renal damage markers (aspartate transaminase, alanine transaminase, alkaline phosphatase, urea, uric acid and creatinine), serum biochemical parameters (total proteins, albumin, cholesterol and glucose) and tissue antioxidant status (superoxide dismutase, catalase, glutathione peroxidase, reduced glutathione and malondialdehyde) were detesrmined. The results of the current study revealed significant improvement in hepatic and renal damage markers after SP supplementation in fish exposed to DZN toxicity. Moreover, SP improved serum biochemical markers through increasing serum albumin and globulins with a significant decrease in serum glucose and cholesterol. In addition, liver, kidneys and gills antioxidant status showed a significant improvement after SP supplemented to fish exposed to DZN where a significant increase in tissue antioxidant activity were observed with a significant decline in lipid peroxidation levels. It can be concluded that, SP supplementation attenuated the toxic effect of DZN toxicity in Nile tilapia through improving liver and kidney functions with a significant enhancement of tissue antioxidant status.

KEYWORDS:

Antioxidant; Diazinon; Nile tilapia; Organophosphate; Oxidative stress; Spirulina

PMID:
28704756
DOI:
10.1016/j.etap.2017.07.002
[Indexed for MEDLINE]

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