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Radiother Oncol. 2015 May;115(2):186-90. doi: 10.1016/j.radonc.2015.04.012. Epub 2015 Apr 29.

Prostate tumor delineation using multiparametric magnetic resonance imaging: Inter-observer variability and pathology validation.

Author information

  • 1Department of Radiation Oncology, The Netherlands Cancer Institute, Amsterdam, The Netherlands.
  • 2Radiation Oncology, University Hospitals Leuven, Department of Oncology, KU Leuven, Belgium.
  • 3Pathology, University Hospitals Leuven, Department of Imaging & Pathology, KU Leuven, Belgium.
  • 4Radiology, University Hospitals Leuven, Department of Imaging & Pathology, KU Leuven, Belgium.
  • 5Department of Radiation Oncology, University Medical Center Utrecht, The Netherlands.
  • 6Department of Radiology, University Medical Center Utrecht, The Netherlands.
  • 7Department of Radiology, The Netherlands Cancer Institute, Amsterdam, The Netherlands.
  • 8Department of Radiation Oncology, The Netherlands Cancer Institute, Amsterdam, The Netherlands. Electronic address: u.vd.heide@nki.nl.

Abstract

BACKGROUND AND PURPOSE:

Boosting the dose to the largest (dominant) lesion in radiotherapy of prostate cancer may improve treatment outcome. The success of this approach relies on the detection and delineation of tumors. The agreement among teams of radiation oncologists and radiologists delineating lesions on multiparametric magnetic resonance imaging (mp-MRI) was assessed by measuring the distances between observer contours. The accuracy of detection and delineation was determined using whole-mount histopathology specimens as reference.

MATERIAL AND METHODS:

Six observer teams delineated tumors on mp-MRI of 20 prostate cancer patients who underwent a prostatectomy. To assess the inter-observer agreement, the inter-observer standard deviation (SD) of the contours was calculated for tumor sites which were identified by all teams.

RESULTS:

Eighteen of 89 lesions were identified by all teams, all were dominant lesions. The median histological volume of these was 2.4cm(3). The median inter-observer SD of the delineations was 0.23cm. Sixty-six of 69 satellites were missed by all teams.

CONCLUSION:

Since all teams identify most dominant lesions, dose escalation to the dominant lesion is feasible. Sufficient dose to the whole prostate may need to be maintained to prevent under treatment of smaller lesions and undetected parts of larger lesions.

KEYWORDS:

Dose escalation; Inter-observer variability; Multiparametric MRI; Prostate cancer; Radiotherapy; Tumor delineation

PMID:
25935742
DOI:
10.1016/j.radonc.2015.04.012
[PubMed - indexed for MEDLINE]
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