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The effects of AICAR and rapamycin on mitochondrial function in immortalized mitochondrial DNA mutator murine embryonic fibroblasts.

Delic V, Noble K, Zivkovic S, Phan TA, Reynes C, Zhang Y, Phillips O, Claybaker C, Ta Y, Dinh VB, Cruz J, Prolla TA, Bradshaw PC.

Biol Open. 2018 Nov 16;7(11). pii: bio033852. doi: 10.1242/bio.033852.


Accumulation of mitochondrial DNA mutations disrupts cardiac progenitor cell function and reduces survival.

Orogo AM, Gonzalez ER, Kubli DA, Baptista IL, Ong SB, Prolla TA, Sussman MA, Murphy AN, Gustafsson ÅB.

J Biol Chem. 2017 Jul 7;292(27):11348. doi: 10.1074/jbc.A115.649657. No abstract available.


Identification of tissue-specific transcriptional markers of caloric restriction in the mouse and their use to evaluate caloric restriction mimetics.

Barger JL, Vann JM, Cray NL, Pugh TD, Mastaloudis A, Hester SN, Wood SM, Newton MA, Weindruch R, Prolla TA.

Aging Cell. 2017 Aug;16(4):750-760. doi: 10.1111/acel.12608. Epub 2017 May 26.


Effects of calorie restriction on the lifespan and healthspan of POLG mitochondrial mutator mice.

Someya S, Kujoth GC, Kim MJ, Hacker TA, Vermulst M, Weindruch R, Prolla TA.

PLoS One. 2017 Feb 3;12(2):e0171159. doi: 10.1371/journal.pone.0171159. eCollection 2017.


Sirt1 deficiency protects cochlear cells and delays the early onset of age-related hearing loss in C57BL/6 mice.

Han C, Linser P, Park HJ, Kim MJ, White K, Vann JM, Ding D, Prolla TA, Someya S.

Neurobiol Aging. 2016 Jul;43:58-71. doi: 10.1016/j.neurobiolaging.2016.03.023. Epub 2016 Mar 30.


Exercise-induced mitochondrial p53 repairs mtDNA mutations in mutator mice.

Safdar A, Khrapko K, Flynn JM, Saleem A, De Lisio M, Johnston AP, Kratysberg Y, Samjoo IA, Kitaoka Y, Ogborn DI, Little JP, Raha S, Parise G, Akhtar M, Hettinga BP, Rowe GC, Arany Z, Prolla TA, Tarnopolsky MA.

Skelet Muscle. 2016 Jan 31;6:7. doi: 10.1186/s13395-016-0075-9. eCollection 2016.


Accumulation of Mitochondrial DNA Mutations Disrupts Cardiac Progenitor Cell Function and Reduces Survival.

Orogo AM, Gonzalez ER, Kubli DA, Baptista IL, Ong SB, Prolla TA, Sussman MA, Murphy AN, Gustafsson ÅB.

J Biol Chem. 2015 Sep 4;290(36):22061-75. doi: 10.1074/jbc.M115.649657. Epub 2015 Jul 16. Erratum in: J Biol Chem. 2017 Jul 7;292(27):11348.


SIRT3 mediates multi-tissue coupling for metabolic fuel switching.

Dittenhafer-Reed KE, Richards AL, Fan J, Smallegan MJ, Fotuhi Siahpirani A, Kemmerer ZA, Prolla TA, Roy S, Coon JJ, Denu JM.

Cell Metab. 2015 Apr 7;21(4):637-46. doi: 10.1016/j.cmet.2015.03.007.


A conserved transcriptional signature of delayed aging and reduced disease vulnerability is partially mediated by SIRT3.

Barger JL, Anderson RM, Newton MA, da Silva C, Vann JA, Pugh TD, Someya S, Prolla TA, Weindruch R.

PLoS One. 2015 Apr 1;10(4):e0120738. doi: 10.1371/journal.pone.0120738. eCollection 2015.


Heterozygous Polg mutation causes motor dysfunction due to mtDNA deletions.

Fuke S, Kametani M, Yamada K, Kasahara T, Kubota-Sakashita M, Kujoth GC, Prolla TA, Hitoshi S, Kato T.

Ann Clin Transl Neurol. 2014 Nov;1(11):909-20. doi: 10.1002/acn3.133. Epub 2014 Oct 22.


Somatic mitochondrial DNA mutations do not increase neuronal vulnerability to MPTP in young POLG mutator mice.

Dai Y, Clark J, Zheng K, Kujoth GC, Prolla TA, Simon DK.

Neurotoxicol Teratol. 2014 Nov-Dec;46:62-7.


Mito-protective autophagy is impaired in erythroid cells of aged mtDNA-mutator mice.

Li-Harms X, Milasta S, Lynch J, Wright C, Joshi A, Iyengar R, Neale G, Wang X, Wang YD, Prolla TA, Thompson JE, Opferman JT, Green DR, Schuetz J, Kundu M.

Blood. 2015 Jan 1;125(1):162-74. doi: 10.1182/blood-2014-07-586396. Epub 2014 Nov 19.


Novel approaches in anaplastic thyroid cancer therapy.

Hsu KT, Yu XM, Audhya AW, Jaume JC, Lloyd RV, Miyamoto S, Prolla TA, Chen H.

Oncologist. 2014 Nov;19(11):1148-55. doi: 10.1634/theoncologist.2014-0182. Epub 2014 Sep 26. Review.


Increased mtDNA mutations with aging promotes amyloid accumulation and brain atrophy in the APP/Ld transgenic mouse model of Alzheimer's disease.

Kukreja L, Kujoth GC, Prolla TA, Van Leuven F, Vassar R.

Mol Neurodegener. 2014 May 2;9:16. doi: 10.1186/1750-1326-9-16.


NAD+ deficiency in age-related mitochondrial dysfunction.

Prolla TA, Denu JM.

Cell Metab. 2014 Feb 4;19(2):178-80. doi: 10.1016/j.cmet.2014.01.005.


Dysregulation of mitochondrial quality control processes contribute to sarcopenia in a mouse model of premature aging.

Joseph AM, Adhihetty PJ, Wawrzyniak NR, Wohlgemuth SE, Picca A, Kujoth GC, Prolla TA, Leeuwenburgh C.

PLoS One. 2013 Jul 23;8(7):e69327. doi: 10.1371/journal.pone.0069327. Print 2013.


Targeted enrichment and high-resolution digital profiling of mitochondrial DNA deletions in human brain.

Taylor SD, Ericson NG, Burton JN, Prolla TA, Silber JR, Shendure J, Bielas JH.

Aging Cell. 2014 Feb;13(1):29-38. doi: 10.1111/acel.12146. Epub 2013 Sep 11.


Behavioral and metabolic characterization of heterozygous and homozygous POLG mutator mice.

Dai Y, Kiselak T, Clark J, Clore E, Zheng K, Cheng A, Kujoth GC, Prolla TA, Maratos-Flier E, Simon DK.

Mitochondrion. 2013 Jul;13(4):282-91. doi: 10.1016/j.mito.2013.03.006. Epub 2013 Mar 27.


Transcriptomics and Metabonomics Identify Essential Metabolic Signatures in Calorie Restriction (CR) Regulation across Multiple Mouse Strains.

Collino S, Martin FP, Montoliu I, Barger JL, Da Silva L, Prolla TA, Weindruch R, Kochhar S.

Metabolites. 2013 Oct 11;3(4):881-911. doi: 10.3390/metabo3040881.


Calorie restriction and SIRT3 trigger global reprogramming of the mitochondrial protein acetylome.

Hebert AS, Dittenhafer-Reed KE, Yu W, Bailey DJ, Selen ES, Boersma MD, Carson JJ, Tonelli M, Balloon AJ, Higbee AJ, Westphall MS, Pagliarini DJ, Prolla TA, Assadi-Porter F, Roy S, Denu JM, Coon JJ.

Mol Cell. 2013 Jan 10;49(1):186-99. doi: 10.1016/j.molcel.2012.10.024. Epub 2012 Nov 29.

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