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J Surg Oncol. 2015 Jul;112(1):66-71. doi: 10.1002/jso.23951.

Prognostic significance of DNA cytometry for adjuvant therapy response in pancreatic cancer.

Author information

1
Department of General, Visceral, and Transplantation Surgery, Charité-Universitätsmedizin Berlin, Berlin, Germany.
2
Department of Medical Oncology and Haematology, Charité-Universitätsmedizin Berlin, Berlin, Germany.
3
Department of Outpatient, Medical Oncology, Friedrichshafen, Germany.

Abstract

BACKGROUND AND OBJECTIVES:

The continuous progress in treatment options for pancreatic adenocarcinoma has lead to a re-evaluation of prognostic markers. In this study the prognostic relevance of DNA Index and classical histopathological parameters with regard to disease-free (DFS) and overall survival (OS) was analyzed within the CONKO-001 patient population.

METHODS:

One hundred forty three fresh-frozen paraffin-embedded tissue samples of the resected tumor specimen of the CONKO-001 patient population were available for DNA index analysis to evaluate its impact on patient outcome.

RESULTS:

Median DFS (7.3 vs. 14.3 months; P = 0.004) and median OS (16.6 vs. 29.2 months; P = 0.011) were significantly decreased in patients with a high DNA index (>1.4). Multivariate analysis revealed both DNA index (DFS: P = 0.002; OS: P = 0.019) and tumor grading (DFS: P = 0.004; OS: P = 0.004) as individual prognostic markers for DFS and OS. The following prognostic subgroups were identified: good (low DNA Index + G1/2 tumor grading), intermediate (low DNA Index + G3 tumor grading or high DNA Index + G1/2 tumor grading), poor (high DNA Index + G3 tumor grading).

CONCLUSION:

The DNA index/tumor grading constellation may serve as a helpful guide for personalized treatment recommendations for adjuvant therapy of patients with pancreatic adenocarcinoma.

KEYWORDS:

CONKO-001; DNA Index; adjuvant therapy; pancreatic adenocarcinoma; tumor grading

PMID:
26193339
DOI:
10.1002/jso.23951
[Indexed for MEDLINE]

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