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J Comput Assist Tomogr. 2016 May-Jun;40(3):343-50. doi: 10.1097/RCT.0000000000000368.

Prognostic Value of Semiautomatic CT Volumetry in Patients With Stage I Non-Small Cell Lung Cancer Treated With Stereotactic Body Radiation Therapy.

Author information

1
From the *PET Center, Kofu Neurosurgical Hospital; †Department of Radiology, University of Yamanashi, Yamanashi; and ‡Department of Radiology, Teikyo University School of Medicine University Hospital, Mizonokuchi, Kawasaki City, Kanagawa Prefecture, Japan.

Abstract

OBJECTIVE:

The aim of this study was to examine the prognostic value of semiautomated 3-dimensional image analysis-based parameters from pretreatment computed tomography (CT) in patients with non-small cell lung cancer treated with stereotactic body radiation therapy.

METHODS:

We evaluated 91 patients. We defined 2 parameters: (1) VOL, extracted tumor volume with a threshold ≥ -400 HU; and (2) ATN, the mean CT attenuation value. The maximum standardized uptake value (SUVmax) was recorded as F-fluorodeoxyglucose positron emission tomography/CT parameter. The prognostic values were assessed using the Kaplan-Meier and a Cox proportional hazards analysis.

RESULTS:

Overall survival and progression-free survival were significantly worse in patients with larger VOL, higher ATN, and higher SUVmax. VOL was an independent indicator of overall survival, whereas ATN was an indicator of progression-free survival, lymph node recurrence, and distant metastasis. However, SUVmax was not an independent prognostic factor for either outcome.

CONCLUSIONS:

VOL and ATN from 3-dimensional image analysis of CT scans have prognostic values for non-small cell lung cancer patients treated with stereotactic body radiation therapy.

PMID:
26854414
DOI:
10.1097/RCT.0000000000000368
[Indexed for MEDLINE]

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